抗炎合剂治疗脓毒症患者应激性高血糖临床观察  

Clinical Observation of Anti-inflammatory Agent Treating Sepsis Patients with Stress Hyperglycemia

作　　者：卜建宏[1] 李越华[1] 闫国良[1] 何文姬[2] 

机构地区：[1]上海市中医医院,上海200071 [2]上海市普陀区人民医院,上海200069

出　　处：《中国中医急症》2014年第9期1617-1619,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：上海市卫生局科研课题(2009177)

摘　　要：目的观察中药抗炎合剂对脓毒症应激性高血糖的疗效。方法将脓毒症并应激性高血糖符合热毒内盛患者74例随机分为两组,对照组采用强化胰岛素疗法控制应激性高血糖,治疗组应用抗炎合剂联合胰岛素非强化治疗,疗程均为7 d。结果治疗组总有效率为74.36%,显著高于对照组的65.71%(P<0.05);治疗后治疗组空腹血糖高于对照组(P<0.05),低血糖的发生率显著低于对照组(P<0.01),胰岛素敏感性改善治疗组优于对照组(P<0.05);治疗组TNF-α、CRP水平均低于治疗组(P<0.01)。结论抗炎合剂对改善脓毒症患者应激性高血糖有效。Objective： To observe the clinical effect of TCM anti-inflammatory agent on sepsis patients with stress hyperglycemia. Methods： 74 patients were randomly divided into control group and treatment group. The two groups were both given conventional treatment. The control group received intensive insulin therapy to control stress hyperglycemia,while the treatment group received anti-inflammatory agent combined with non-intensive insulin treatment to control stress hyperglycemia. At the end of trial, clinic effects of both groups were compared. Results： After treatment,incidence of hypoglycemia,APACHE Ⅱ score and TCM syndrome score in treatment group were better than those in control group. The treatment group could effectively inhibit the release of inflam- matory cytokines and insulin resistance,which was better than the control group. Conclusion： The anti-inflam- matory agent is effective for sepsis patients with stress hyperglycemia.

关 键 词：脓毒症 应激性高血糖 胰岛素抵抗 炎症因子 抗炎合剂 

分 类 号：R631[医药卫生—外科学]