血必净注射液对高海拔地区老年肺部感染患者CD4^+CD25^+调节性T细胞的影响  

Effect of Xuebijing Injection on CD4^+CD25^+ Regulatory T Cells in Elderly Patients with Pulmonary Infection at High Altitude

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作  者:王春雨[1] 罗晓红[1] 付学锋[1] 张新宇[1] 

机构地区:[1]兰州军区兰州总医院,甘肃兰州730050

出  处:《中国中医急症》2014年第9期1696-1698,共3页Journal of Emergency in Traditional Chinese Medicine

基  金:甘肃省科技厅自然科学基金资助项目(1010RJZA052)

摘  要:目的观察血必净注射液对高海拔地区老年肺部感染患者CD4+CD25+调节性T细胞的影响。方法将48例患者随机分为两组,对照组给予抗感染综合治疗,干预组在综合治疗基础上加用血必净注射液静滴7 d。流式细胞仪检测治疗前、治疗第7日外周血CD4+CD25+调节性T细胞比例,并比较两组临床疗效。结果与治疗前比较,干预组CD4+CD25+调节性T细胞比例下降明显(P<0.05),平均治疗时间明显缩短。结论血必净注射液在治疗高海拔地区老年肺部感染时能调节细胞免疫,提高疗效。Objective: To observe the effect of Xuebijing Injection on CD4^+CD25^+ regulatory T cells in elderly patients with pulmonary infection at high altitude. Methods: 48 patients with pulmonary infection were randomly divided into two groups: intervention group and control group. Patients in both groups were given comprehensive anti-infection treatment. Additionally,Xuebijing Injection was given intravenously in intervention group for 7 days. The changes of proportions of CD4^+CD25^+ regulatory T cells were detected by flow eytometry respectively before treatment and on the 7th day after treatment. Durations and prognosis of all patients were recorded. Results: Pro- portions of CD4^+CD25^+ regulatory T cells decreased significantly on 7th day in intervention group compared with those in control group (P 〈 0.05). Furthermore,therapeutic time in intervention group was shortened obviously. Conclusion: Xuebijing Injection can regulate cyto-immunologic function in elderly patients with pulmonary in- fection at high altitude and improve therapeutic effect.

关 键 词:血必净注射液 CD4^+CD25^+调节性T细胞 高海拔地区 肺部感染 老年 

分 类 号:R563[医药卫生—呼吸系统]

 

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