慢性乙型肝炎及慢性丙型肝炎患者混合感染GBV-C的队列研究  

Cohort Study on Pathogenicity of Hepatitis G Virus Mixed Infection with Hepatitis B and C Virus

作　　者：李朋[1] 朱万孚[1] 安文锋[1] 李志杰[1] 王淑平 庄辉[1] 

机构地区：[1]北京大学基础医学院病原生物学系微生物学教研室,北京100083 [2]河南省周口市卫生防疫站

出　　处：《中国公共卫生》2002年第8期911-913,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金资助项目 批准号 :39870 695

摘　　要：目的　探讨GB病毒C(GBV -C)的致病性 ,以及混合感染GBV -C后对慢性乙型肝炎及慢性丙型肝炎预后的影响。方法　对我国河南省某市 95例慢性乙型肝炎患者及某农村 80例慢性丙型肝炎患者进行了现况调查 ,并于其后 6个月及 2 0个月进行前瞻性队列研究。结果　GBV -C混合感染率在慢性乙型肝炎患者中为 2 0 0 %～ 2 5 0 % ,在慢性丙型肝炎患者中为 2 8 3%～ 33 5 %。混合感染GBV -C后 ,对于慢性肝炎患者的肝功能水平未产生显著影响。结论　表明在慢性乙型肝炎和慢性丙型肝炎患者中 ,未发现混合感染GBV -C明显加重肝损伤 。Objective To study the pathogenicity of GB virus C(GBV-C),and effect of coinfection with GBV-C on hepatitis B and C.Methods GBV-C was determined in sera of 95 patients who were diagnosed as chronic hepatitis B and 80 patients of hepatitis C.Cohort study for 6,20 months was conducted.Results The rate of HBV and GBV-C mixed infection was 20 0%～25 0% and rate of HCV and GBV-C mixed infection was 28 3%～33 5%.Serum ALT,AST,TBil,etc were compared between with and without GBV-C infecton.No significant difference was found between the two groups.GBV-C did not effect the clearance of HBV and HCV.Conclusion The study suggested that mixed infection of GBV-C did not lead to significant effect on patients with chronic hepatitis B and hepatitis C.It was lack of pathogenicity that GBV-C existed in liver disease.

关 键 词：慢性乙型肝炎 慢性丙型肝炎 混合感染 GBV-C 队列研究 

分 类 号：R512.6[医药卫生—内科学]