微囊藻毒素LR对SD孕鼠胎盘的损伤作用研究  

Damage Effect of Microcystin on Placenta in SD Pregnant Rats

作　　者：卫国荣[1] 张占英[1] 连民[1] 刘颖[1] 俞顺章[1] 张幼辰[1] 陈伟炜[1] 

机构地区：[1]复旦大学公共卫生学院预防医学研究所,上海200032

出　　处：《中国公共卫生》2002年第8期921-922,共2页Chinese Journal of Public Health

基　　金：国家自然科学基金资助项目 (39730 380 )

摘　　要：目的　探讨微囊藻毒素LR(MicrocystinsLR ,MCLR)对SD孕鼠胎盘的损伤作用。方法　采用整体动物模型观察器官形成期暴露给MCLR对大鼠胎盘的损伤和对宫内胚胎发育的影响。结果　不同剂量的MCLR均可损伤胎盘屏障 ,在停止注射 6天后 ,仍可造成整个胎盘细胞变性、水肿和间质疏松。结论　MCLR可直接对胎盘产生毒性作用 ,损伤胎盘屏障并改变其通透性 ,使得MCLR容易进入胎盘而影响胚胎形成和发育。Objective To study the damage effects of Microcystin LR(MCLR) on placenta in Sprague-Dawley rats(SD rats).Methods SD rats were injected with MCLR in their embryo forming period to study the effects of MCLR to the placenta and the embryo development.Results Different dose of MCLR can directly injure the placenta barrier and entered into the embryo,which affected the forming and delopment of embryo.The placenta pathological slices showed that there were degeneration,dropsy and interstitium loosen in all placenta cells on the sixth day stopping injection of MCLR.Conclusion MCLR could injure the placenta barrier directly which made MCLR easily enter the embryo and effect the forming and development of embryo.

关 键 词：微囊藻毒素LR 胎盘 损伤 研究 

分 类 号：R114[医药卫生—卫生毒理学]