空气动力波联合前列地尔治疗糖尿病下肢动脉硬化闭塞症的临床观察  

Clinical observations on aerodynamic wave plus Alprostadil for the treatment of diabetes lower limb arteriosclerosis obliterans

作　　者：余红梅[1] 胡清[1] 曾玉琴[1] 汪晓芬[1] 王娜娜[1] 龚丽[1] 李雪锋[1] 

机构地区：[1]湖北医药学院附属太和医院,湖北十堰442000

出　　处：《现代中西医结合杂志》2014年第29期3199-3201,3219,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：2011年湖北省教育厅科研项目(D20112105)

摘　　要：目的观察空气动力波联合前列地尔治疗糖尿病下肢动脉硬化症的临床疗效,并探讨其治疗机制。方法将符合纳入标准的54例患者随机分为2组,治疗组34例采用空气动力波联合前列地尔治疗,对照组20例仅采用前列地尔治疗,治疗2个疗程后评定2组临床疗效,并观察治疗前后下肢动脉血管内径、血流量及踝肱指数的变化情况。结果治疗2个疗程后,治疗组疗效优于对照组(P<0.05);治疗组下肢血管内径、血流量、踝肱指数改善程度均优于对照组(P均<0.05)。结论空气动力波联合前列地尔治疗糖尿病下肢动脉硬化症安全有效,其疗效优于单一前列地尔治疗。Objective It is to observe the clinical efficacy of aerodynamic wave plus Alprostadil on diabetic lower limb arteriosclerosis obliterans,and to explore its mechanism.Methods 54 patients with diabetic lower limb arteriosclerosis obliterans were randomly allocated to treatment groups of 34 cases and control groups of 20 cases,the treatment group were treated with Aerodynamic wave plus Alprostadil,the control group were treated with Alprostadil only.After two treatment courses,the clinical curative effects of both groups were assessed,and the changes of blood vessel diameter of lower extremity artery,blood flow and ankle brachial index（ABI） before and after treatment were observed.Results After two treatment courses,the curative effect of treatment group was better than that of control group（P〈0.05）,and the improvements of blood vessel diameter of lower extremity artery,blood flow and ABI were also better than those of control group（P〈0.05）.Conclusion Aerodynamic wave plus Alprostadil is effective and safe in the treatment for diabetic lower limb arteriosclerosis obliterans.Its effect is superior to that of treatment with Alprostadil only.

关 键 词：糖尿病下肢动脉硬化闭塞症 空气动力波 前列地尔 

分 类 号：R587.2[医药卫生—内分泌]