依帕司他联合前列地尔治疗2型糖尿病周围神经病变的疗效  

Analysis of the Efficacy of Epalrestat Combined with Alprostadil for the Treatment of Type 2 Dia-betic Perineuropathy

作　　者：高四红 郑桃林[2] 何伟[2] 

机构地区：[1]陕西省安塞县人民医院内科,陕西延安717400 [2]解放军163医院神经内科,湖南长沙410003

出　　处：《医学临床研究》2014年第8期1569-1571,共3页Journal of Clinical Research

摘　　要：【目的】观察依帕司他联合前列地尔治疗糖尿病周围神经病变（DPN）的临床疗效。【方法】将88例2型糖尿病（T2DM）DPN的患者随机分为对照组与观察组，各44例，两组患者均严格控制饮食、适量运动、口服降糖药或注射胰岛素控制血糖，甲钴胺注射液0．5 mg肌注，每日1次。在此基础上，观察组加用依帕司他50 mg口服，每日3次；前列地尔20μg＋0．9％氯化钠注射液100 m L静脉滴注，每日1次。疗程均为2周。【结果】观察组患者自觉症状改善总有效率（97．7％）显著高于对照组（72．7％）（P＜0．05）；两组神经传导速度（NCV）均明显改善，观察组优于对照组，差异具有统计学意义（P＜0．01）。【结论】依帕司他、前列地尔及甲钴胺注射液联合治疗DPN效果显著。[Objective]To observe clinical efficacy of epalrestat combined with alprostadil for the treatment of diabetic perineuropathy（DPN） .[Methods] Totally 88 patients with type 2 diabetes mellitus（T2DM） peripheral neuropathy were randomly divided into control group （ n =44） and observation group（ n = 44） .Patients in two groups received strict diet control ,appropriate exercise ,oral blood glucose lowering drug or insulin injection to control blood glucose ,and also intramuscular injection with mecobalamin 0 .5mg once daily .On the basis of the treatment of the control group ,the observation group additionally received oral epalrestat 50mg 3 times per day and alprostadil 20 μg＋ 0 .9% sodium chloride by intravenous injection once daily .The treatment course was 2 weeks .[Results] The total effective rate of the improvement of subjective symptoms in observation group （97 .7% ） was significantly higher than that in control group（72 .7% ）（ P〈0 .05） .Motor nerve conduction velocity （MNCV） in two groups was obviously improved ,and the improvement in observation group was better than control group , and there was significant difference （ P 〈 0 .01） .[Conclusion] The combination of epalrestat ,alprostadil and mecobalamine injection is markedly effective in the treatment of DPN .

关 键 词：绕丹宁/治疗应用 绕丹宁/类似物和衍生物 前列地尔/治疗应用 维生素B12/治疗应用 注射剂 药物疗法 联合 糖尿病神经病变/药物疗法 治疗结果 

分 类 号：R587.25[医药卫生—内分泌]