健脾消胀片对大鼠胆汁分泌的影响  

Effect of Jianpi Xiaozhang Tablets on Biliation in Rats

作　　者：耿秀丽[1] 马珍珍[1] 郝少君[1] 张正臣[1] 

机构地区：[1]解放军第371中心医院,河南新乡453000

出　　处：《中国药师》2014年第9期1475-1477,共3页China Pharmacist

基　　金：河南新乡市重点科技攻关计划(编号:ZG12012)

摘　　要：目的:观察健脾消胀片对大鼠胆汁分泌的影响。方法:大鼠60只,分为6组,分别灌服健脾消胀片(大、中、小剂量)混悬液;舒胆通混悬液;清肝利胆胶囊混悬液和同体积的0.5%羧甲基纤维素;每天给药1次,连续给药5 d。收集各组大鼠胆汁量,检测胆汁中总胆汁酸、总胆固醇、总胆红素等含量。结果:健脾消胀片可使大鼠胆汁中胆汁酸、胆红素含量显著升高(P<0.01),胆固醇含量显著降低(P<0.01)。结论:健脾消胀片有促进胆汁分泌的作用。Objective： To observe the effect of Jianpi Xiaozhang tablets on the bile secretion in rats. Methods： Totally 60 rats were divided into 6 groups randomly. Jianpi Xiaozhang tablet suspension （ high, moderate, tow dosages）, Shudantong suspension, Qinggan Lidan capsule suspension and 0.5% carboxymethyl cellulose with the same volume was respectively given with intragastric gavage once daily for continuous 5 days. The bile was collected to detect total bile acids （TBA） , total cholesterol and total bilirubin. Re- suits： Jianpi Xiaozhang tablets could notably increase TBA and total bilirubin in the bile （P 〈 0.01 ）, and decrease the cholesterol content significantly （P 〈 0.01 ）. Conclusion ： Jianpi Xiaozhang tablets can promote the bile secretion.

关 键 词：健脾消胀片 大鼠 胆汁分泌 舒胆通片 清肝利胆口服液 

分 类 号：R285.5[医药卫生—中药学]