正交试验法优选消炎颗粒提取工艺  

Optimization of Extraction Technology of Xiaoyan Granules by Orthogonal Test

作　　者：仇继玺[1] 张振巍[1] 李园园[1] 石磊[1] 

机构地区：[1]解放军第155中心医院药械科,河南开封475003

出　　处：《中国药师》2014年第9期1478-1480,共3页China Pharmacist

基　　金：济南军区科研计划(编号:CJN10L067)

摘　　要：目的:优选消炎颗粒的提取工艺。方法:利用正交试验法考察加水量、煎煮时间、煎煮次数等因素对提取工艺的影响,以干浸膏得率和秦皮乙素含量为考察指标,烘干法测定干浸膏得率,高效液相色谱法测定秦皮乙素含量。结果:加8倍量水,煎煮1.5 h,煎煮3次为最佳提取工艺。结论:正交试验法筛选消炎颗粒的提取工艺可行、方法简便,制备的颗粒质量合格稳定。Objective ： To optimize the extraction process of Xiaoyan granules. Methods： The extraction process was optimized by orthogonal test with water volume, extraction times and extraction duration as the influencing factors. The dry extract rate and esculetin content were used as the evaluation indices. The dry extract rate was determined by drying method, and esculetin was determined by HPLC. Results ： The optimal extraction conditions were as follows ： water was 8 times of the medicinal materials, the decoction duration was 1.5h with 3 extraction times. Conclusion： The optimized process of Xiaoyan granules is feasible and convenient, and the granules are qualified and stable.

关 键 词：正交试验法 消炎颗粒 提取工艺 高效液相色谱 

分 类 号：R284.2[医药卫生—中药学]