固体脂质纳米粒的研究新进展  

New progress of study on solid lipid nanoparticles

作　　者：丁立新[1] 柴佳丽[1] 李焕[1] 杨珊珊[1] 于莲[1] 李守君[1] 王佐卿[1] 

机构地区：[1]佳木斯大学药学院,黑龙江省生物药制剂重点实验室,黑龙江佳木斯154007

出　　处：《中国民康医学》2014年第20期69-71,共3页Medical Journal of Chinese People’s Health

基　　金：黑龙江省教育厅科学技术研究项目(12521559)

摘　　要：目的:综述固体脂质纳米粒的研究新进展。方法:参阅国内外大量有代表性的论文,进行分析、归纳和总结。结果:比较了五种方法制备固体脂质纳米粒的优、缺点,其中以微乳化法和高压乳匀法(HPH)制备固体脂质纳米粒方法较好。介绍了固体脂质纳米粒的理化性质及其研究方法,讨论了适合于固体脂质纳米粒的不同给药途径。结论:固体脂质纳米粒作为一种新型的给药系统,虽存在一些问题有待解决,但却是一个很有发展前景的新型给药系统。Objective：To review new progress of solid lipid nanoparticles （ SLN） . Methods：Lots of typical thesis from home and abroad were analyzed and summarized. Results： In comparison with advantages and disadvantages of five methods for preparing SLN, especially it＆#39;s better way to prepare SLN by microemulsion technique and high pressure homogenization （ HPH） . Physicochemi-cal property and their analytical methods were introduced and different administration routes of SLN were discussed. Conclusions：As a new drug delivery system, SLN is reported to be a development in future though some problems existing need to be solved.

关 键 词：固体脂质纳米粒 制备方法 理化性质 

分 类 号：R944.2[医药卫生—药剂学]