血清甲状腺激素与甲状腺动脉血流动力学相关性分析  

Correlation between serum thyroid hormone and hemodynamics of thyroid artery

作　　者：于一飞[1] 蒋莹[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院超声诊断科,上海200025

出　　处：《诊断学理论与实践》2014年第3期303-307,共5页Journal of Diagnostics Concepts & Practice

摘　　要：目的：探讨甲状腺弥漫性疾病患者的彩色多普勒超声血流参数及其与甲状腺激素水平间的关系。方法：分析1 252例次[甲状腺功能亢进（甲亢）585例次,亚临床甲亢161例次,甲状腺功能减低（甲减）186例次,亚临床甲减122例次,正常组198例次]的甲状腺彩色多普勒超声检测血流参数与甲状腺激素[游离三碘甲状腺原氨酸（free trnodothyronine,FT3）和游离四碘甲状腺素（free thyroxine,FT4）]水平间的相关性。结果：甲亢组的甲状腺上动脉收缩期峰值流速（peak systolic velocity,PSV）、PSV×心率（heart rate,HR）及甲状腺体积均显著高于其他各组（P〈0.01）。在甲亢组中PSV、PSV×HR及甲状腺体积分别与血清FT3、FT4呈正相关（P〈0.01）,且其与血清FT3的相关度较FT4高;血清FT3在5.70-15.00 pmol/L范围时（正常范围2.63-5.70 pmol/L,上限值46.08 pmol/L）,甲状腺上动脉超声血流参数与其相关性较高,且两者间的相关性随着血清FT3水平的升高而显著下降,当血清FT3近检测上限范围时,两者不相关;而在其他组中,两者呈低度相关或不相关。结论：彩色多普勒超声检查可在一定程度上反映甲状腺功能状态,并可辅助用于甲状腺弥漫性疾病临床诊治。Objective： To investigate the correlation between hemodynamics of thyroid artery on color Doppler ultrasonography and thyroid hormone levels in diffuse thyroid disease. Methods： The correlations between data of color Doppler flow imaging （CDFI） and levels of serum thyroid hormones （FT3, FT4） from 1 252 cases （585 cases with hyperthyroidism, 161 cases with subclinical hyperthyroidism, 186 cases with hypothyroidism, 122 cases with subclinical hypothyroidism and 198 cases of normal controls） were analyzed. Results： The peak systolic velocity （PSV） of superior thyroid artery, PSV×heart rate （HR） and thyroid volume in hyperthyroidism group were significantly higher than those in the other groups （P〈0.01）. In hyperthyroidism group, PSV, PSV×HR and thyroid volume were positively correlated with serum FT3 and FT4 （P〈0.01）, and had a higher correlation with FT3 level than with FT4 level. In the range of 5.70-15.00 pmol/L （normal range： 2.63-5.70 pmol/L, upper limit： 46.08 pmol/L）, the correlation between FF3 level and hemodynamics on CDFI was quite high. However, the correlation decreased gradually with the increase in FT3 level, and when the FT3 level reaching the upper limit, the correlation became statistically insignificant. In other groups, the correlations were statistically insignificant. Conclusions： Blood flow parameters of thyroid artery on CDFI has a statistical correlation with thyroid function status, which would be helpful for the clinical diagnosis and management of diffuse thyroid disease.

关 键 词：彩色多普勒血流成像 甲状腺上动脉 甲状腺弥漫性疾病 甲状腺激素 

分 类 号：R445.1[医药卫生—影像医学与核医学]