高龄高血压患者双下肢动脉闭塞症的危险因素分析  

Risk factors of peripheral arterial occlusive diseaseof two lower extremitiesin very old patients with hypertension

作　　者：邢云利[1] 周震[2] 孙颖[1] 黄樱硕[1] 黄蔚[1] 

机构地区：[1]首都医科大学附属北京友谊医院老年病科,北京100050 [2]首都医科大学生物医学工程学院,北京100069

出　　处：《中华老年多器官疾病杂志》2014年第8期573-577,共5页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：首都医科大学基础和临床科研合作基金（13JL57）;北京市保健科研课题（京09-02）

摘　　要：目的：探讨高龄高血压患者双下肢动脉闭塞症（PAOD）的危险因素。方法入选2012年8月至2013年8月首都医科大学附属北京友谊医院老年病科高龄高血压患者121例，收集临床资料，进行下肢动脉超声以及动态血压监测。根据下肢动脉超声结果将其分为PAOD组（n＝49）和非PAOD组（n＝72）。用SPSS 16.0软件包进行独立样本t检验、相关性分析和logistic回归分析。结果高龄高血压患者PAOD发病率为40.5%。PAOD组年龄、冠心病发生率、血肌酐以及糖化血红蛋白（HbA1c）水平较非PAOD组患者明显升高（P＜0.05）。logistic回归表明年龄、冠心病、白昼平均收缩压（dDBP）、HbA1c是PAOD的独立危险因素。回归方程：PAOD＝-12.169＋0.131×年龄＋1.341×冠心病-0.069×dDBP＋HbA1c×0.692。结论高龄高血压患者PAOD的发生率显著高于普通人群。年龄、冠心病、dDBP、HbA1c是PAOD的独立危险因素。ObjectiveTo determine the risk factors for peripheral arterial occlusive disease （PAOD） in the very old patients with hypertension.Methods Totally 121 very old hypertensive subjects with age over 80yearsand systolic blood pressure≥140mmHg admitted in our department from August 2012 to August 2013 were enrolled in this study. Their clinical data were collected. Lower extremity arteries ultrasonography and ambulatory 24-hour blood pressure monitoring were carried out. They were divided into PAOD group （n=49） and non-PAOD group （n=72） accordingtothe results of lower extremity artery ultrasonography. Independentsamplest-test, correlation analysis and logistic regression analysis were employed to analyze the risk factors. Results The morbidity of PAOD was 40.5% in the very old patients with hypertension. PAOD patients had significantly higher age, incidence of coronary heart disease （CHD）, serumcreatinine and glycosylated hemoglobin A1c （HbA1c） level （P〈0.05）. Logistic regression analysis revealed thatage, CHD, averageday diastolic blood pressure （dDBP） andHbA1c were independent risk factors for PAOD （regression equation： PAOD=-12.169＋0.131×age＋1.341×CHD-0.069×dDBP＋HbA1c×0.692）. Conclusion The morbidity of PAOD is significantly higher in the very old patients with hypertension thaninordinary population. Age, CHD, dDBP and HbA1c are independent risk factors for PAOD.

关 键 词：老年人 高血压 动脉闭塞性疾病 

分 类 号：R544.1[医药卫生—心血管疾病]