益气和血通络方对大鼠实验性心肌缺血氧化应激反应的影响  

Effect of Yiqi Hexue Tongluo Prescription on Oxidative Stress of Experimental Myocardial Ischemia in Rats

作　　者：钟慧群[1] 赵芸芸[2] 张文风[1] 

机构地区：[1]长春中医药大学基础医学院,吉林长春130117 [2]长春中医药大学第一临床学院,吉林长春130117

出　　处：《中医药信息》2014年第5期12-13,共2页Information on Traditional Chinese Medicine

基　　金：吉林省教育厅课题(No.吉教科合字【2014】第476号)

摘　　要：目的:观察益气和血通络方对大鼠心肌缺血氧化应激反应的影响。方法:尾静脉单次注射垂体后叶素(Pit),建立大鼠心肌缺血损伤模型,观察各组大鼠的心电图ST段变化、血清中超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量的变化。结果:益气养血通络方能改善垂体后叶素引起的急性心肌缺血心电图变化,提高血清SOD活性、降低MDA含量。结论:益气和血通络方可提高心脏抗氧化能力,对垂体后叶素引发的大鼠急性心肌缺血损伤具有明显保护作用。Objective ：To observe the effect of Yiqi Hexue Tongluo prescription on oxidative stress of experimen- tal myocardial ischemia in rats. Method：Myocardial ischemia injury models were established by a single injec- tion of pituitrin （Pit）on rats＇tail vein. Observe Ecg ST segment changes between groups of rats ,changes of Ser- um Chinese super oxide dismutase （SOD） activity , and changes of malondialdehyde （MDA） content. Re- suits ： Yiqi Hexue Tongluo prescription could improve changes of acute myocardial ischemia ecg caused by pitu- itrin. The prescription could also increase the serum SOD activity and reduce the MDA contents. Conclusion： Yiqi Hexue Tongluo prescription can improve cardiac antioxidant capacity, and it has an obviously protective effect on acute myocardial ischemic injury of rats caused by pituitrin.

关 键 词：益气和血通络方 垂体后叶素 心肌缺血 

分 类 号：R285.5[医药卫生—中药学]