大鼠尾静脉注射姜黄素固体脂质纳米粒的药动学研究  

Pharmacokinetics Study of Curcumin Solid Lipid Nanoparticles by Intravenous Injection in Rats

作　　者：晏子俊[1] 李万玉[1] 孙立力[1] 邓雪[1] 万坤[1] 张景勍[1] 

机构地区：[1]重庆医科大学药物高校工程研究中心和生物化学与分子药理学重点实验室,重庆400016

出　　处：《中药材》2014年第7期1234-1236,共3页Journal of Chinese Medicinal Materials

基　　金：重庆市科委重点项目(CSTC2012JJB10027)

摘　　要：目的:研究SD大鼠尾静脉注射姜黄素固体脂质纳米粒后的药动学情况。方法:大鼠尾静脉注射姜黄素固体脂质纳米粒和游离药姜黄素后,不同时间点取血浆,HPLC测定血浆中姜黄素的含量,得其药时曲线,并以DAS软件分析处理药动学数据。结果:姜黄素固体脂质纳米粒和游离药姜黄素的药动学参数分别如下:AUC0-t为(173.09±44.81)μg·h/L和(114.83±13.19)μg·h/L,AUC0-∞为(196.56±35.25)μg·h/L和(120.66±13.95)μg·h/L,t1/2为(5.95±2.05)h和(1.46±0.03)h,姜黄素固体脂质纳米粒的AUC0-t、AUC0-∞和t1/2分别提高了1.50、1.63、4.08倍。结论:姜黄素固体脂质纳米粒在大鼠体内消除慢,能明显提高姜黄素的生物利用度。Objective： To study the intravenous pharmacokinetics of curcumin solid lipid nanoparticles in SD rats.Methods： Rats were administrated with（ iv） curcumin solid lipid nanoparticles and curcumin solution（ 8.0 mg /kg）,respectively.Blood samples were collected and curcumin in blood plasma was determined by HPLC.Compartmental pharmacokinetics was analyzed by DAS software.Results： After intravenous administration,the AUC0-t、AUC0-∞and t1 /2of curcumin solid lipid nanoparticles were 1.50-fold,1.63-fold and 4.08-fold higher than those of curcumin solution as（ 173.09 ± 44.81） μg · h /L vs.（ 114.83 ± 13.19） μg · h /L,（ 196.56 ±35.25） μg·h/L vs.（ 120.66 ±13.95） μg·h/L and（ 5.95 ±2.05） h vs.（ 1.46 ±0.03） h.Conclusion： The curcumin solid lipid nanoparticles is eliminated more slowly.The bioavailability of curcumin in rats increases remarkably compared with that of curcumin solution after intravenous administration.

关 键 词：姜黄素 固体脂质纳米粒 尾静脉注射 药代动力学 

分 类 号：R285.5[医药卫生—中药学]