以纳米笼形POSS为交联剂的PHEMA水凝胶的制备及其对诺氟沙星的缓释行为  

Preparation of PHEMA Hydrogels with a Nano Cagelike POSS as Cross-Linker and Its Drug Release Behaviour of Norfloxacin

作　　者：张晓静[1] 胡跃磊 李翀[1] 李斌[1] 方少明[1] 

机构地区：[1]郑州轻工业学院材料与化学工程学院,河南省表界面科学重点实验室,郑州450002

出　　处：《功能高分子学报》2014年第3期296-301,共6页Journal of Functional Polymers

基　　金：国家自然科学基金(20804041)

摘　　要：以甲基丙烯酸β-羟乙酯（HEMA）为单体、笼形八聚（乙烯基）倍半硅氧烷（OVPS）为交联剂,通过溶液自由基聚合方法制备了一系列P（OVPS-co-HEMA）水凝胶。采用核磁共振氢谱（1 H-NMR）、傅里叶红外光谱（FT-IR）、扫描电镜（SEM）、差示扫描量热仪（DSC）、热重分析仪（TG）、动态黏弹谱仪（DMA）和紫外可见分光光度计对其结构与性能进行了研究。结果表明：通过控制投料比可以调节P（OVPS-co-HEMA）水凝胶中OVPS的含量;随着OVPS投料比例的增加,水凝胶的交联密度变大,孔洞直径由10~15μm逐渐减小至5~10μm;OVPS的引入增强了水凝胶的力学强度;P（OVPS-co-HEMA）水凝胶对药物诺氟沙星具有良好的控释作用,达到释药平衡的时间为96h,累计释药率最高可达99.56%,可用于接触镜片、人工角膜和组织工程材料。A novel series of P（OVPS-co-HEMA）hydrogels were prepared by the solution free radical polymerization using hydroxyethyl methacrylate（HEMA）as monomer and octavinyl polyhedral oligomeric silsesquioxane（OVPS）as the cross-linker.The structure and properties of hydrogels were characterized by1 H-NMR,FT-IR,SEM,DSC,TG,DMA and UV technologies.Results show that the mass fraction of OVPS in P（OVPS-co-HEMA）hybrid hydrogels can be controlled by the feed ratios of the copolymerization.The cross-linking density of P（OVPS-co-HEMA）hydrogels increases with the increasing of the OVPS mass fraction.The sizes of the hydrogel holes decrease from 10-15μm to 5-10μm.The mechanical property of P（OVPS-co-HEMA）hydrogels is improved with the incorporation of OVPS.The P（OVPSco-HEMA）hydrogels display an excellent norfloxacin-controlled release behavior.The drug release time is about 96 hand the cumulative release percentage can reach 99.56%.The P（OVPS-co-HEMA）hydrogels can be potentially used as contact lens,keratoprosthesis and tissue engineering materials.

关 键 词：笼形低聚倍半硅氧烷 聚甲基丙烯酸β-羟乙酯 水凝胶 

分 类 号：O63[理学—高分子化学] TQ31[理学—化学]