电磁脉冲对清醒大鼠尾动脉血压的影响  

Effects of Electromagnetic Pulses on Caudal Arterial Blood Pressure of Conscious Rats

作　　者：李宝丰[1] 陈蓓[2] 李梅[1] 章莹[1] 赵涛[3] 李静[3] 任东青[3] 郭国祯[3] 

机构地区：[1]广州军区广州总医院骨科医院,广东广州510010 [2]广州军区广州总医院肿瘤科,广东广州510010 [3]第四军医大学放射医学教研室,陕西西安710032

出　　处：《现代生物医学进展》2014年第32期6201-6204,共4页Progress in Modern Biomedicine

基　　金：国家自然科学青年基金项目(81000819)

摘　　要：目的:观察电磁脉冲(electromagnetic pulses,EMP)对清醒大鼠动脉血压和心率的影响。方法:适应性血压测量1周后的14只健康成年雄性SD大鼠按体重随机分为假辐照组和辐照组,每组7只,在锥形平板GTEM小室内接受EMP辐照,EMP辐照参数为:场强200 kV/m,脉冲前沿3.5 ns,脉宽14 ns,重复频率1 Hz,辐照后用无创性尾套式血压测量仪测量2 hr至1 wk内大鼠动脉血压和心率变化规律。结果:照后3 d大鼠动脉血压(收缩压、舒张压和平均动脉压)与假辐照组相比下降显著(P<0.05),12 h有下降趋势,其他时间未见显著性差异(P>0.05);辐照对大鼠心率也无明显影响(P>0.05)。结论:EMP辐照可以引起大鼠血压一过性降低;对大鼠心率无明显影响。Objective： To investigate the effects of electromagnetic pulses （EMP） on arterial blood pressure and heart rate of con- scious rats. Methods： 14 male Sprague-Dawley rats, the blood pressure of which have been measured for a week, were randomly divided into two groups with 7 rats for each group. They were subjected to sham exposure or 200 kV/m [200 kV/m, 3.5 ns duration, 14 ns width, llqz and 200 pulses] EMP fields in a tapered parallel plate GTEM cell. The arterial blood pressures and heart rates were evaluated from 2 hours to 1 week after exposures by a noninvasive tail-cuff photoelectric sensor sphygmomanometer. Results： 3d after the EMP irradia- tion, arterial blood pressures [systolic, mean and diastolic pressures] decreased significantly（P〈0.05）. There was a tendency to decrease at the 12th hour after exposures. There was no significant differences at other times （P〉0.05）. There was no change in heart rates by the exposures （P 〉 0.05 ）. Conclusion： EMP irradiation can decrease the arterial blood pressures of conscious rats in a short period of time. No influence of EMP was detected on the heart rate.

关 键 词：电磁脉冲 动脉血压 心率 大鼠 

分 类 号：Q95-3[生物学—动物学] Q64