阻塞性睡眠呼吸暂停低通气综合征患者血浆CF6水平及其与血压的关系  

The Blood Level of CF6 in Patients with Obstructive Sleep Aspnea hypopnea Syndrome and its Link with Blood Pressure

作　　者：林琳[1] 于波[1] 路瑞华 于汉力[1] 张若溪[1] 陈树源 

机构地区：[1]哈尔滨医科大学附属第二医院心血管内科,黑龙江哈尔滨150001 [2]黑龙江省中医药科学院心病科,黑龙江哈尔滨150036

出　　处：《现代生物医学进展》2014年第30期5874-5876,5873,共4页Progress in Modern Biomedicine

基　　金：国家十一五科技攻关项目(2004BA706B11)

摘　　要：目的:研究阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆线粒体偶联因子6(CF6)水平并探讨其与OSAHS患者血压的关系。方法:对45名OSAHS患者、20名高血压患者以及15名健康体检者进行研究。所有受试者接受整夜多导睡眠监测以及血压测量。根据有无高血压分为OSAHS合并高血压组(Ⅰ组)以及单纯OSAHS组(Ⅱ组),单纯高血压组(Ⅲ组)以及健康对照组(Ⅳ组)。分析比较多导睡眠监测结果,将Ⅰ组中12例首诊高血压且未服药物的OSAHS患者作为OSAHS合并初诊高血压组(A组)。匹配年龄、性别、是否吸烟以及体重指数,从Ⅱ组和Ⅲ组中分别随机选择11名OSAHS血压正常患者和11名初诊高血压且未服用药物患者分别作为单纯OSAHS组(B组)以及单纯高血压组(C组),选择10例健康体检者作为健康对照组(D组)。四组共44例研究对象均于次日清晨采空腹肘静脉血,采用酶联免疫吸附法检测血浆CF6水平。结果:健康对照组(D组)、单纯OSAHS组(B组)和单纯高血压组(C组)、OSAHS合并高血压组(A组)血浆CF6水平明显递增,且OSAHS合并高血压组血浆CF6水平明显高于单纯OSAHS组和单纯高血压组,但单纯OSAHS组和单纯高血压组之间无明显差别。结论:OSAHS患者血浆CF6水平显著升高,其可能通过减少前列环素I2(PGI2)的合成导致OSAHS患者继发高血压。Objective： To test the blood level of chondrosome coupling factors 6 （CF6）, and to investigate the link between CF6 and blood pressure in patients with aspnea hypopnea syndrome （OSAHS） complicated hypertension. Methods： Polysomnography was performed in 45 patients with OSAHS, 20 patients with hypertension （group Ⅲ）and in 15 healthy controls （group Ⅳ ）. According to complicating hypertension or not, OSAHS patients were divided into two groups, OSAHS with hypertension group（group Ⅰ） and OSAHS without hypertension（group Ⅱ ）. The polysomnography results were compared among four groups. After excluded the patients who Were taking medicine and complicated with the severity infect and other organ disease, we selected 12 OSAHS patients with hypertension diagnosed for the first time（group A） from groupⅠ . Matched age, gender, smoking and body mass index （BMI）, 11 OSAHS patients without hypertension and 11 patients with hypertension were randomly selected from group Ⅱ and III as simple OSAHS group （group B）and hypertension group （group C）. 10 healthy controls were randomly selected as group D. Blood samples from 44 patients were taken in the morning, plasma CF6 was measured by enzyme linked immunosorbent assay （ELISA）. Results： Matched age, gender and smoking, plasma CF6 level in group A, B and C were significantly higher than that in group D. Furthermore, plasma CF6 level in group A was remarkably higher than that in group B and C. There was no difference between group B and C. Conclusion： The level of CF6 in patients with OSAHS is increased, and it may elevate the blood pressure by decreasing the synthesizing of PGI2.

关 键 词：阻塞性睡眠呼吸暂停低通气综合征 高血压 偶联因子6 机制 

分 类 号：R56[医药卫生—呼吸系统]