磁共振扩散张量成像在儿童创伤性胼胝体损伤中的应用研究  

Application of Magnetic Resonance Diffusion Tensor Imaging in Evaluating Traumatic Corpus Callosum Injury in Children

作　　者：董景敏 王红霞 姜兴岳 陈亮 冯艳 王培源 张林 

机构地区：[1]医学院附属医院放射科,滨州256603 [2]医学院临床学院,滨州256603

出　　处：《临床放射学杂志》2014年第9期1408-1411,共4页Journal of Clinical Radiology

基　　金：滨州医学院科技计划项目(编号:BY2011KJ050);山东省自然科学基金资助项目(编号:ZR2011HL038)

摘　　要：目的探讨磁共振扩散张量成像(DTI)在儿童创伤性胼胝体损伤中的应用价值。方法实验组12例,对照组12名,所有患者均在外伤后的14天之内进行检查。常规磁共振检查后,行DTI扫描,分别测量实验组、对照组相应感兴趣区的各向异性分数(FA)值,用t检验分析感兴趣区域的FA值,并对实验组的FA值与格拉斯哥昏迷评分(GCS)进行相关性分析。结果胼胝体膝部(FA=0.621±0.02)、压部(FA=0.608±0.04)的FA值较对照组明显下降(P<0.05);胼胝体压部的FA值与GCS评分相关性较好(P<0.05)。结论 DTI可以较常规MRI检查更敏感地发现弥漫性轴索损伤病灶,FA值可作为评估儿童创伤性胼胝体损伤病情严重程度的敏感指标。Objective To investigate the application of MR diffusion tensor imaging （DTI） in evaluating traumatic cor- pus callosum injury in children. Methods The patients were divided into study group （ n = 12） and control group （ n = 12）. MR scanning was performed within 14 days after the trauma. Conventional MRI was followed by DTI scanning. The fractional anisotropy （FA） of region of interest （ROI） was measured in all patients of both groups. FA values were statisti- cally analyzed by using t test, and the correlation of FA values of the study group with Glasgow coma score （GCS） was ana- lyzed. Results The FA values of genu and splenium of corpus callosum in the study group were （0. 621± 0.02） and （0. 608 ± O. 04） respectively, which were significantly lower than those in the control group （P 〈 0.05 ）. A positive correlation existed between FA value of splenium of corpus callosum and the GCS score （P 〈 O. 05 ）. Conclusion DTI is more sensi- tive in detecting DAI lesions than conventional MRI. FA value can be used as a sensitive index to evaluate the traumatic se- verity of the corpus callosum in children.

关 键 词：儿童 胼胝体损伤 扩散张量成像 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]