不同对比剂对脑转移瘤MRI动态增强定量参数(K^trans)的影响  

Influence of Different Contrast Agents on Dynamic Contrast-Enhanced MRI K^(trans) in Cerebral Metastases:Comparison between 1.0 M Gadobutrol and 0.5 M Gadopentetate Dimeglumine

作　　者：范兵[1,2] 杜华睿[3] 王霄英[1] 宛然[1] 罗晶晶[1] 张珏[3] 

机构地区：[1]北京大学第一医院医学影像科,100034 [2]宜昌市夷陵医院,443100 [3]北京大学前沿交叉研究院,100000

出　　处：《临床放射学杂志》2014年第9期1421-1424,共4页Journal of Clinical Radiology

摘　　要：目的比较不同浓度对比剂(钆布醇与钆喷酸葡胺)对脑转移瘤容积转移常数(Ktrans)的影响。方法招募10例脑转移瘤患者,签署知情同意书,采用个体内自身随机对照研究,所有患者均接受2次头颅MRI动态增强检查,分别注射2种不同对比剂。采用交叉设计,利用随机表确定注射钆布醇和钆喷酸葡胺的次序,两次检查间隔24~48 h。对比剂剂量0.1 mmol/kg体重,注药流率3.0 ml/s,注射对比剂同时启动MR动态增强检查,对直径>5 mm的病灶测量Ktrans值及细胞外血管外间隙(Ve)值。使用SPSS 13.0进行统计学处理,对2种不同对比剂所测Ktrans值及Ve值分别采用方差分析,进一步做Pearson相关性分析,P<0.05认为有统计学差异。结果 2例患者因病灶较小(直径<5 mm)无法测量Ktrans值而排除,对8例患者共21个病灶进行分析,钆布醇及钆喷酸葡胺所测Ktrans值分别为(0.32±0.19)min-1,(0.35±0.19)min-1(F=0.315,P>0.05),两者Ve值分别为0.89±0.10,0.88±0.09(F=0.009,P>0.05)。两种对比剂所测Ktrans值及Ve值均呈正相关(Ktrans:r=0.712,P<0.001;Ve:r=0.616,P<0.05)。结论使用不同含钆对比剂(钆布醇与钆喷酸葡胺)行MR动态增强扫描,对脑转移瘤病灶所测Ktrans及Ve值具有相关性。Objective To explore the effect of different Gadolium-based contrast agents （ gadobutrol vs. gadopentetate dimeglumine） on the measurement of volume transfer constant （K ） and Ve in dynamic contrast enhanced MRI for cere- bral metastases. Methods Ten patients with pathologically-confirmed cerebral metastases were examined by dynamic con- trast-enhanced MR imaging with identical scanning protocol for two times. Gadobutrol or gadopentetate dimeglumine were randomly selected for the first study, with dosage of 0.1 mmol gadolium/kg body weight. Twenty-four to 48 hours later, the second study was performed with injection of the other contrast agent. The K^trans and Ve values of the metastatic foci were obtained from the 2 sets of data. Paired t test and Pearson correlation analysis were used for statistical analysis. Results Two patients were excluded because the lesions were too small （diameter less than 5mm）. Thus, 8 patients （21 lesions in total） could be used for evaluation. The K^trans values obtained with gadobutrol and gadopentetate dimeglumine contrast-en- hanced dynamic MRI were （0.32 ~0.19） min-1 and （0.35 ±0.19） min-1 , respectively. And the Ve values were （0.89±0.10） and （0. 88 ±0. 09）, respectively. For both K^trans and Ve, Paired t test showed that no statistically significant differences existed between values obtained with the two different contrast agents. Both K^trans and Ve measurements obtained with gadobutrol were correlated with measurements obtained with gadopentetate dimeglumine （ K^trans： r = 0. 712, P 〈 0. 001 ; Ve： r = 0. 616, P 〈 0.05）. Conclusion On dynamic contrast enhanced MRI for cerebral metastases, the Kt and Ve values that are measured when gadobutrol is used have good correlation to the K^trans and Ve values that are measured when gadopentetate dimeglumine is used.

关 键 词：钆布醇 钆喷酸葡胺 脑转移瘤 容积转运常数 

分 类 号：R445.2[医药卫生—影像医学与核医学]