锥形束CT与螺旋CT图像配准算法及其在放疗中的应用  

The Image Registration of Cone-Beam CT and Spiral CT:Application to Radiation Therapy

作　　者：沈奕晨[1,2] 聂生东[1] 

机构地区：[1]上海理工大学医学影像工程研究所,上海200093 [2]上海交通大学医学院附属新华医院肿瘤科,上海200092

出　　处：《中国医学物理学杂志》2014年第5期5151-5156,共6页Chinese Journal of Medical Physics

基　　金：国家自然科学基金项目(60972122);上海市教委科研创新项目(14ZZ135)

摘　　要：目的:随着肿瘤放射治疗的发展,提高肿瘤放射治疗的精确度成为了重要的发展趋势。通过硬件与软件的共同发展,实现在线纠正治疗误差在医学图像帮助下完成放疗是现今临床研究的热点。图像引导放射治疗就是在这样理念的基础上发展出来的新型放疗模式。本文研究的目的就是阐述在现今临床普遍采用的锥形束CT与螺旋CT的图像配准在肿瘤放射治疗中的实际应用与重要性。通过研究总结出一套系统化的肿瘤放射治疗图像配准理论,发现最新研究热点、阐述最新研究不足,为今后进一步的发展图像引导放射治疗打下基础。方法:本文通过阐述基本医学图像配准理论,结合具体图像配准算法,应用于图像引导放射治疗,总结出一套系统化用于锥形束CT与螺旋CT图像配准的模式,从而获得更加快速准确的配准结果,改善图像引导放射治疗的效率。本文查阅了近几年计算机软件图像处理的大量文献,同时结合查阅大量图像引导放射治疗的文献,总结前人经验结合理论实践,综合阐述了一套应用于图像引导放射治疗的图像配准系统。结果:锥形束CT与螺旋CT的图像配准,在临床应用上多使用刚性图像配准,其有速度快便于计算的优势。但涉及到患者整体体位配准情况下,弹性图像配准在配准准确度上具有明显优势,需结合临床实际需求以及计算机运算能力的发展想结合选择合适的配准算法。结论:随着肿瘤放射治疗中图像引导技术的应用,螺旋CT定位图像与锥形束CT治疗图像的配准是图像引导放射治疗的关键技术,如何准确而且快速的获取配准结果成了精确放射治疗关注的焦点。螺旋CT定位图像与锥形束CT治疗图像的精确配准是精确放射治疗的前提,并在提高肿瘤剂量的同时,最大限度的保护正常组织,从而提高肿瘤放射治疗的疗效。本文主要综述了应用于精确放射治疗中�Objective：With the development of radiation oncology,to improve the accuracy has become an important trend.Though the help of hardware and software,online correction of treatment has become a hot research subject.The IGRT is a new mode of radiation therapy on the base of these theories.This article is to elaborate on the importance of image registration（CBCT and Spiral CT） in radiation therapy.This article sums a systematic theroy of image registration,discovers new research,elaborates shortcoming of the latest research,and makes the foundation of late research.Methods：This article sums a mode of image registration in IGRT by the basic image registration theory and IGRT theory.The mode can improve the efficiency of IGRT and get the result of image registration quckly.In this paper,we summarize vast aticle about image registration and IGRT in radiation therapy.Results：We use rigid image registration of CBCT and Spiral CT more in IGRT beacause of calculation＇s speed.But the position of treatment haselastic deformation.The elastic image registration ismore accurate than the rigid image registration.It can solve the problem of elastic deformation.So our choice of image registraion must depand on needs of clinical and power of computing.Conclusions：With the application of Image-Guided Radiation Therapy in radiation oncology,the image registration of Cone-Beam CT and Spiral CT is the key of the IGRT.How accurate and fast access to get the registration results have become the focus.The accurate image registration of CBCT and Spiral CT in radiation therapy is the premise of precise radiotherapy.It can improve get higher target dose,protect the organs at risk.This paper briefly introduces the image registration of Cone-Beam CT and Spiral CT applies to the precise radiotherapy.

关 键 词：锥形束CT 螺旋CT 图像配准 图像引导放射治疗 

分 类 号：TP312[自动化与计算机技术—计算机软件与理论]