Effects of surround suppression on response adaptation of V1 neurons to visual stimuli  

作　　者：Peng LI Cai-Hong JIN San JIANG Miao-Miao LI Zi-Lu WANG Hui ZHU Cui-Yun CHEN Tian-Miao HUA 

机构地区：[1]College of Life Sciences,Anhui Normal University

出　　处：《Zoological Research》2014年第5期411-419,共9页动物学研究（英文）

基　　金：supported by the National Natural Science Foundation of China(31171082);the Natural Science Foundation of Anhui Province(070413138);the Key Research Foundation of the Anhui Provincial Education Department(KJ2009A167);the Foundation of Key Laboratories of Anhui Province and the Anhui Provincial Education Department

摘　　要：The influence of intracortical inhibition on the response adaptation of visual cortical neurons remains in debate. To clarify this issue, in the present study the influence of surround suppression evoked through the local inhibitory interneurons on the adaptation effects of neurons in the primary visual cortex （V1） were observed. Moreover, the adaptations of V1 neurons to both the high-contrast visual stimuli presented in the classical receptive field （CRF） and to the costimulation presented in the CRF and the surrounding nonclassical receptive field （nCRF） were compared. The intensities of surround suppression were modulated with different sized grating stimuli. The results showed that the response adaptation of V1 neurons decreased significantly with the increase of surround suppression and this adaptation decrease was due to the reduction of the initial response of V1 neurons to visual stimuli. However, the plateau response during adaptation showed no significant changes. These findings indicate that the adaptation effects of V1 neurons may not be directly affected by surround suppression, but may be dynamically regulated by a negative feedback network and be finely adjusted by its initial spiking response to stimulus. This adaptive regulation is not only energy efficient for the central nervous system, but also beneficially acts to maintain the homeostasis of neuronal response to long-presenting visual signals.The influence of intracortical inhibition on the response adaptation of visual cortical neurons remains in debate. To clarify this issue, in the present study the influence of surround suppression evoked through the local inhibitory interneurons on the adaptation effects of neurons in the primary visual cortex （V1） were observed. Moreover, the adaptations of V1 neurons to both the high-contrast visual stimuli presented in the classical receptive field （CRF） and to the costimulation presented in the CRF and the surrounding nonclassical receptive field （nCRF） were compared. The intensities of surround suppression were modulated with different sized grating stimuli. The results showed that the response adaptation of V1 neurons decreased significantly with the increase of surround suppression and this adaptation decrease was due to the reduction of the initial response of V1 neurons to visual stimuli. However, the plateau response during adaptation showed no significant changes. These findings indicate that the adaptation effects of V1 neurons may not be directly affected by surround suppression, but may be dynamically regulated by a negative feedback network and be finely adjusted by its initial spiking response to stimulus. This adaptive regulation is not only energy efficient for the central nervous system, but also beneficially acts to maintain the homeostasis of neuronal response to long-presenting visual signals.

关 键 词：Surround suppression V1 neurons Response adaptation CAT 

分 类 号：Q42[生物学—神经生物学]