RhoA/ROCK信号通路在动脉粥样硬化发生中的作用  

Pathophysiology role of Rho A / ROCK signalling pathway in progression of atherosclerosis

作　　者：李南南[1] 张军平[2] 仲爱芹[1] 吕仕超[1] 

机构地区：[1]天津中医药大学研究生院,天津300073 [2]天津中医药大学第一附属医院心内科,天津300073

出　　处：《基础医学与临床》2014年第10期1422-1425,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(81173244)

摘　　要：Rho A/ROCK通路参与细胞肌动蛋白骨架的调节、细胞的收缩、黏附、增生、分化及基因的表达等。越来越多的证据表明,其在动脉粥样硬化的发生发展中起着重要作用。对Rho A/ROCK通路的研究将拓展对有关心血管疾病的认识,有望为心血管疾病提供新的治疗靶点。RhoA/ROCK signaling pathway is ubiquitously involved in regulation of actin cytoskeleton and various cell behaviors,including cell contraction,adhesion,proliferation,gene expression,and so on.In the past few decades,accumulated experimental and clinical evidences suggest that it plays an important role in atherosclerosis.Thus,identification of the molecular mechanisms and inhibition of RhoA/ROCK pathway will undoubtedly deepen our understanding of cardiovascular disease and even maybe a promising therapeutic target.

关 键 词：RHOA Rho相关激酶 动脉粥样硬化 分子机制 

分 类 号：R543.5[医药卫生—心血管疾病]