白介素6、内皮素1和E选择素与心脑血管病关系的巢式病例对照研究  

A nested case-control study in studying the relationship between interleukin-6, endothelin-1,E-selectin and the risk of cardio-cerebrovascular events

作　　者：陈秋艳[1] 卜晓青[1] 刘艳[1] 徐娟[1] 孔凡龙[1] 汪桂艳 张永红[1] 

机构地区：[1]苏州大学医学部公共卫生学院流行病与卫生统计学教研室,215123 [2]厦门市妇幼保健院预防保健科

出　　处：《中华流行病学杂志》2014年第10期1151-1154,共4页Chinese Journal of Epidemiology

基　　金：基金项目：国家自然科学基金（30972531）

摘　　要：目的：研究白介素6（IL-6）、内皮素1（ET-1）及E选择素（E-selectin）与心脑血管事件发生的关系。方法在对2589名蒙古族人群连续随访10年的队列研究基础上，采用巢式病例对照研究方法，分析IL-6、ET-1和E-selectin与心脑血管事件发生的关系，利用logistic回归分析方法计算OR值及其95%CI。结果病例组与对照组的IL-6（7.66 vs.8.77 pg/ml）、ET-1（0.74 vs.0.75 pg/ml）和E-selectin（17.96 vs.18.32 ng/ml）的差异无统计学意义（P＞0.05）。logistic分析表明，与IL-6≤23.91 pg/ml或ET-1≤1.33 pg/ml或E-selectin≤24.43 ng/ml者相比，IL-6＞23.91 pg/ml或ET-1＞1.33 pg/ml或E-selectin＞24.43 ng/ml者发生心脑血管事件的多因素调整后的OR值及其95%CI分别为0.69（0.41～1.16）、1.10（0.66～1.85）和1.19（0.71～2.00），差异均无统计学意义（P＞0.05）。结论调查人群中基线IL-6、ET-1及E-selectin水平与心血管事件危险性无显著关联。Objective To investigate the relationship between interleukin-6（IL-6）,endothelin-1 （ET-1）,E-selectin and the risk of cardio-cerebrovascular events. Methods Based on a cohort study in which 2 589 Mongolians had been followed up for 10 years,a nested case-control study was carried out to analyze the relationship between IL-6, ET-1, E-selectin and the risk of cardio-cerebrovascular events. Logistic regression analysis was used to calculate the odds ratio（OR） and 95%confidence intervals（95%CI）. Results The average level of IL-6（7.66 vs. 8.77 pg/ml）, ET-1（0.74 vs. 0.75 pg/ml） and E-selectin （17.96 vs. 18.32 ng/ml） were not significantly different between the case and the control groups（P〉0.05）. Data from the logistic regression analysis showed that IL-6,ET-1 and E-selectin were not significantly associated with the risk of cardio-cerebrovascular events. The multivariable adjusted ORs（95%CI）on the risk of cardio-cerebrovascular events were 0.69 （0.41-1.16）,1.10 （0.66-1.85） and 1.19（0.71-2.00） for the participants with IL-6〉23.91 pg/ml ,ET-1〉1.33 pg/ml and E-selectin〉24.43 ng/ml,respectively,compared with those having IL-6≤23.91 pg/ml ,ET-1≤1.33 pg/ml or E-selectin≤24.43 ng/ml. Conclusion Data from our study indicated that the levels of IL-6,ET-1 and E-selectin at baseline were not significantly associated with the risk of cardio-cerebrovascular events in people from Inner Mongolia.

关 键 词：心脑血管病 炎症 关联强度 巢式病例对照 

分 类 号：R54[医药卫生—心血管疾病] R181.3[医药卫生—内科学]