中老年人血尿酸与空腹血糖的相关性分析  

Association between serum uric acid and fasting plasma glucose in middle and elderly Chinese

作　　者：余永杰[1] 江朝强[1] 靳雅丽[1] 徐琳[2] 刘斌[1] 张维森 郑家强[3] 林大庆[2] 

机构地区：[1]广州医科大学附属市十二人民医院,510620 [2]香港大学公共卫生学院 [3]英国伯明翰大学公共卫生与流行病学系

出　　处：《中华流行病学杂志》2014年第10期1155-1159,共5页Chinese Journal of Epidemiology

基　　金：基金项目：广州市科技计划（200222-E0251）;广州市2012年第十五批科技资助项目（2012J5100041）

摘　　要：目的：探讨中老年人FPG与血尿酸（SUA）的相关性。方法研究对象来自广州生物库中老年队列第一期基线资料收集时10413名年龄≥50岁的广州市居民，按照不同FPG水平分组，分析FPG与SUA及高尿酸血症（HUA）的相关性。结果女性SUA水平及HUA检出率随FPG水平升高而增加，各FPG组间的差异均有统计学意义（趋势检验P＜0.05）。男性SUA水平及HUA检出率在糖尿病（DM）组、IFG组间的差异均无统计学意义（P＞0.05），且高于FPG正常组（P＜0.05）。按不同FPG水平分组与HUA建立多因素logistic回归模型，在调整年龄、吸烟、饮酒、体力活动以及BMI、TG、SCr、高血压等相关因素后，女性患HUA的风险随FPG水平升高而明显增加（趋势检验P＜0.01），当出现IFG时（FPG 6.1～6.9 mmol/L），女性患HUA的风险增加40%（95%CI：1.19～1.64），受检者诊断为DM与非DM者相比，女性患HUA的风险增加44%（95%CI：1.15～1.79），而男性患HUA的风险则与FPG水平的升高无明显相关（趋势检验P＞0.05）。结论中老年女性SUA水平及HUA检出率随FPG水平升高而增加；FPG水平的升高使女性HUA患病风险增加，而男性则未见此现象。Objective To examine the association of fasting plasma glucose （FPG） and serum uric acid （SUA） in middle and elderly Chinese. Methods 10 413 Guangzhou residents aged ≥50 were included in the present study. Information on personal history,physical examination and biochemical parameters were collected. Subjects were grouped by the FPG level,association between FPG and SUA. Levels of hyperuricemia（HUA）were evaluated. Results The SUA levels and the incidence of HUA showed trends of increasing,with the increasing FPG levels in women,with statistically significant differences seen among all the FPG groups（P value for trend〈0.05）. While the statistical differences of SUA levels and the incidence rates of HUA among diabetes group（DM group）and impaired fasting glucose（IFG）groups were non-significant（P〉0.05）but it was higher than normal FPG group in men （P〈0.05）. Logistic regression models were built between various FPG groups and HUA. After adjusting for age,smoking status,drinking status,physical activity, hypertension,body mass index and the levels of triglyceride and creatin. When compared to the normal FPG group,the risk of women suffering from HUA increased by 40%（95%CI：1.19-1.64） under the FPG in the range of 6.1-6.9 mmol/L. Compared to those non-diabetic individuals,the risk of diabetic patients suffering from HUA also increased by 44%（95%CI：1.15-1.79） in women. However,the risk of suffering from HUA did not relate to the increase of FPG in men. Conclusion The SUA level and the incidence of HUA tended to increase along with the increasing levels of FPG in middle and elderly Chinese women and the increase of FPG might also increase the risk of HUA,but not in men.

关 键 词：高尿酸血症 空腹血糖 血尿酸 中老年人 

分 类 号：R589.7[医药卫生—内分泌]