体质量指数在慢性非传染性疾病和健康相关生命质量间的调节效应  

Body mass index as a moderator of the relationship between chronic disease and health-related quality of life

作　　者：史会梅[1] 朱燕波[1] 

机构地区：[1]北京中医药大学管理学院,100029

出　　处：《中华流行病学杂志》2014年第10期1160-1163,共4页Chinese Journal of Epidemiology

基　　金：基金项目：国家重点基础研究发展计划（973计划）（2011CB505403）;国家自然科学基金（30873256）;北京市共建项目

摘　　要：目的：探讨BMI在慢性非传染性疾病（慢病）和健康相关生命质量（HRQOL）间的调节变量和调节效应作用。方法从汇集9省市21948名调查对象的数据库中随机抽取性别、年龄结构与2005年全国1%人口抽样调查样本数据一致的8448人作为数据源，从中选择数据完整的8314名研究对象作为样本。采用多层回归分析方法研究变量间的调节效应。结果以HRQOL得分为因变量的回归方程中，交互作用项“慢病× BMI”的回归系数和新增解释量在SF-36生理领域均无统计学意义（β＝0.084，P＝0.142；ΔR2＝0.000，P＝0.142），在心理领域均有统计学意义（β＝0.132，P＝0.034；ΔR2＝0.001，P＝0.034）。标准化回归系数比较发现，生理领域和心理领域均为“慢病”（-0.259；-0.187）对HRQOL的影响大于“BMI”（0.082；0.095）。结论 BMI在慢病和心理领域HRQOL之间存在调节效应。BMI值越高，慢病对心理领域HRQOL的负向影响越小。Objective To examine the function of body mass index（BMI）as a moderator reflecting the relationship between chronic disease and health-related quality of life（HRQOL）. Methods This study included 8 314 participants pooled from a general population-based cross-sectional survey that had been conducted in Beijing and 8 provinces of China（Jiangsu,Anhui,Gansu, Qinghai,Fujian,Jilin,Jiangxi,and Henan）. Hierarchical multiple regression was emplayed to test the moderating effect. Results In physical component summary of SF-36,the regression coefficient of interaction on chronic disease and BMI was not significantly different（β=0.084,P=0.142）,while the new ΔR2 was not significantly different （ΔR2=0.000,P=0.142） either. In mental component summary of SF-36,the interaction on chronic disease and BMI was significantly different（β=0.132, P=0.034）,so as the new ΔR2（ΔR2=0.001,P=0.034）. Compared to the standard regression coefficient,chronic disease had a greater negative impact on HRQOL than BMI on both physical and mental component summaries. Conclusion Our results indicated that BMI could moderate the association between chronic disease and HRQOL. The higher the BMI,the smaller negative impact of chronic disease on HRQOL in mental component summary was seen.

关 键 词：体质量指数 慢性非传染性疾病 健康相关生命质量 调节效应 

分 类 号：R195[医药卫生—卫生统计学]