血栓弹力图在评估肝癌患者高凝状态中的作用  

The role of thromboelastography in evaluating hypercoagulability in patients with hepatic carcinoma

作　　者：董晓锋[1,2] 周健[1,3] 兰帅奇 郝新建[1,2] 叶昱坪[1,2] 王艳[1,2] 

机构地区：[1]河南省肿瘤医院 [2]郑州大学附属肿瘤医院输血科,河南郑州450008 [3]郑州大学附属肿瘤医院血液科,河南郑州450008

出　　处：《中国输血杂志》2014年第9期931-933,共3页Chinese Journal of Blood Transfusion

基　　金：2011年河南省医学科技攻关计划普通项目(2011020167)

摘　　要：目的探讨血栓弹力图（TEG）在评估肝癌患者凝血功能中的作用。方法选择本院2013年1月～2013年12月确诊肝癌患者316名,检测TEG、常规凝血试验和深静脉血管超声多普勒检查,根据深静脉血栓形成情况分为血栓形成组、无血栓组和对照组,比较此3组患者上述检查指标的差异。结果血栓形成组患者与无血栓组比较q=14.706,血栓形成组与无血栓组比较q=20.744,组间比较差异有统计学意义（P〈0.05）;其余各项检测参数间的差异无统计学意义（P〉0.05）。结论肝癌患者TEG中R值升高提示患者处于高凝状态,有血栓形成可能。Objective To investigate the role of thromboelastography （TEG） in assessing coagulation status in patients with hepatocellular carcinoma （HCC）. Methods TEG, routine coagulation tests and venous Doppler ultrasound were done to detect the coagulation status in 316 patients who were diagnosed with HCC from January to December in 2013. The patients were divided into two groups：group 1 was diagnosed with deep vein thrombosis and group 2 was not diagnosed with thrombosis,in addition to a control group consisting of non-HCC patients with normal liver function. The detection results were compared among the three groups. Results The difference of R values （q = 14.706） between group 1 and group 2, and （ q = 20. 744） between group 1 and control demonstrated significant differences between group 1 and group 2, and group 1 and control （ P 〈 0. 05） ; no statistically significant difference was found in the other test parameters among the three groups（ P 〉 0. 05 ）. Conclusion Increased R value in TEG may indicate hypereoagulability and predict the high risk for deep vein thrombosis formation in patients with HCC.

关 键 词：血栓弹力图 凝血试验 肝癌 静脉血栓 

分 类 号：R457.1[医药卫生—治疗学] R730.5[医药卫生—临床医学]