输血对胃癌化疗患者疗效及预后的影响  

The impact of transfusion on prognosis and outcomes of chemotherapy in gastric cancer patients

作　　者：叶先仁[1] 刘景福[1] 陈玉娟[1] 王娜[1] 卢荣[1] 

机构地区：[1]福建省肿瘤医院输血科,福建福州350014

出　　处：《中国输血杂志》2014年第9期933-935,共3页Chinese Journal of Blood Transfusion

摘　　要：目的探讨贫血的胃癌患者在化疗期间输血对其疗效及预后的影响。方法收集263例接受化疗且治疗期间Hb最低值≤100 g/L的胃癌患者临床资料,单因素及多因素分析包括输血在内的各种因素对化疗疗效及预后的影响。结果多因素logistic回归分析结果显示,输血（P〈0.05,95%CI 0.226～0.762）和化疗前低Hb水平（P〈0.05,95%CI 0.341～0.998）是影响化疗近期疗效的独立因素。Kaplan-Meier法及Log-rank检验的生存分析结果显示,输血组生存率显著低于未输血组（P〈0.05）,多因素COX回归分析结果提示仅根治性手术是影响患者预后的独立因素（P〈0.05）。结论化疗期间的输血是影响胃癌患者的化疗疗效以及生存率的因素之一。Objeetive To examine the impact of transfusion on prognosis and outcomes of chemotherapy in anaemic gas- tric cancer patients. Methods Retrospective data were collected from 263 gastric cancer patients whose nadir hemoglohin levels were less than 100 g/L during chemotherapy. Patients＇ clinical factors, which included transfusion, were analyzed by univariate analysis and multivariate analysis. Results Multivariate logistic regression analysis showed that transfusion （ P 〈0. 05,95 % CI 0. 226 -- 0. 762 and hemoglobin level of pre-ehemotherapy （ P 〈 0. 05,95 % CI 0.341 - 0.998） were independ- ent risk factors for chemotherapy response rate. The survival rate of patients with transfusion was significantly lower than that of those without transfusion （P 〈 0. 05 ）. Multivariate Coxregression analysis showed that radical surgery was the only independent factor for survival prognosis （P 〈 0. 05 ）. Conclusion Blood transfusion is one of the factors that affects the chemotherapy response and the survival of gastric cancer patients under chemotherapy.

关 键 词：输血 胃肿瘤 化疗 预后 

分 类 号：R457.1[医药卫生—治疗学] R730.5[医药卫生—临床医学]