基于乳化剂配比变化的乳膏微观结构与稳定性关联性研究  

Correlation Study on Microstructure and Stability of Cream Based on Changes in Compound Proportion of Mixed Emulsifiers

作　　者：尹辉府[1] 王森[1] 李荣苗[1] 朱卫丰[1] 

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,南昌330004

出　　处：《世界科学技术-中医药现代化》2014年第8期1688-1695,共8页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家"十一五"科技支撑计划项目(2008BA153B071):适宜中药特点的软膏制剂油水分散共性技术研究;负责人:朱卫丰;江西省科技厅学科学术和技术带头人培养技术专项(20123BCB22007):中药乳膏液晶胶网结构构建与稳定研究;负责人:朱卫丰;江西省科技厅自然科学基金项目(20122BAB205071):中药乳膏剂液晶胶网结构的构建与稳定规律研究;负责人:王森;江西中医药大学校级研究生创新基金(JZYC12B03)

摘　　要：目的:利用因子分析探讨含司盘-吐温复配乳化剂乳膏的微观结构与物理稳定性之间的关联性。方法:通过显微观察、流变测量等技术表征乳膏微观结构;利用热重技术及近红外稳定性分析技术定量表征乳膏物理稳定性。结果:在司盘60-吐温80和司盘60-吐温60复配乳化剂乳膏中,随着司盘60比例的增加,乳膏电导值及其在50℃-70℃内失去的水有逐渐增加的趋势,偏光下呈现的球形层状液晶结构逐渐清晰且增多,70℃-110℃失去的水有逐渐降低的趋势。而黏弹性呈现先增后减的趋势,且司盘与吐温的比例分别在2∶2、1∶3时黏弹性最强。结论:稳定性与微观结构公因子关联性分析表明:乳膏在各种实验条件下的稳定性与乳膏"结构密集度"、"结构抗破坏能力"呈正相关,与"亲水凝胶相水分分布指数"呈负相关。This article was aimed to study the correlation between microstructure and stability of cream contained Span and Tween as compound emulsifier by factor analysis. Techniques such as microscopic observation and rheolog-ical examination were used to perform the microstructure. And the thermal analysis and near-infrared stability ana-lyzer was carried out to quantify characterization of the physical stability of cream. The results showed that among the series of S60-T80 and S60-T60 creams based on compound emulsifier, cream conductivity increased and more and more spherical lamellar liquid crystalline structures appear on micrographs with increasing Span 60 fraction. The greatest viscoelastic was appeared when the mass ratio of Span and Tween was 2：2 and 1：3, respectively. From the thermogravimetric analysis, the increase of Span 60 fraction led to the weight loss of samples between 50℃-70℃ in-crease, but it decreased within 70℃-110℃. It was concluded that there was positive correlation between the intensi-ty of microstructure and the ability of resistance to structural failure when the experiment conditions were stable. It had negative correlation with the hydrophilic gel phase water distribution index.

关 键 词：微观结构 因子分析 流变测量 相关性 

分 类 号：R284[医药卫生—中药学]