中药干预TGF-β1/Smad通路抗肾间质纤维化的研究概况  

General research of renal interstitial fibrosis on Chinese medicine intervention TGF-beta 1/Smad pathway

作　　者：谢明明[1] 康永[1] 邸彦清 张曾亮[1] 

机构地区：[1]内蒙古医科大学中医学院,内蒙古呼和浩特010110

出　　处：《内蒙古中医药》2014年第25期103-104,共2页Inner Mongolia Journal of Traditional Chinese Medicine

摘　　要：肾间质纤维化是慢性肾脏疾病的典型特征,肾间质纤维化最突出的特点是肾间质细胞外基质过度沉积。转化生长因子β1(transforminggrowthfactor-β1TGF-β1)是肾纤维化发展的重要介体,Smad蛋白是TGF-β1信号的关键下游介质。目前中药治疗肾间质纤维化的研究中,大量的注意力集中在TGF-β1/Smad通路。本研究就中药干预TGF-β1/Smad通路抗肾间质纤维化的研究概况作一综述。Renal interstitial fibrosis is a typical feature of chronic kidney disease,its most outstanding characteristic is renal interstitial excessive deposition of extracellular matrix.Transforming growth factor-β1 （TGF-β1） is important mediators in the development of renal fibrosis. Smad proteins is the key of TGF-β1 signal downstream medium. In the study of traditional Chinese medicine treatment of renal interstitial fibrosis recently, there is a lot of attention on the TGF-beta/Smad pathway. This study was reviewed the Chinese medicine intervention about TGF-β1 / Smad nathwav of renal interstitial fibrosis.

关 键 词：中药 TGF-β1/Smad通路 肾间质纤维化 研究概况 

分 类 号：R2-03[医药卫生—中医学]