参松养心胶囊对老年冠心病患者血清总抗氧化能力的影响  

Influence of Shensong Yangxin Capsules on Total Antioxidative Capability in Elderly Patients with Coronary Heart Disease

作　　者：定腊平 林韬[1] 刘尧[1] 白春锦[2] 

机构地区：[1]沈阳军区司令部沈阳第二干休所卫生所,辽宁沈阳110035 [2]沈阳医学院附属第二医院心内科

出　　处：《沈阳医学院学报》2014年第3期147-148,156,共3页Journal of Shenyang Medical College

摘　　要：目的:观察参松养心胶囊对老年冠心病患者血清总抗氧化能力(total antioxidant capacity,TAOC)的影响。方法:选择2010年6月至2014年4月门诊就诊的老年冠心病患者82例(观察组),连续应用参松养心胶囊≥12个月。另选择未服用过参松养心胶囊的老年冠心病患者80例为对照组。2组患者基线及12个月后进行血清TAOC及丙二醛(MDA)的检测。结果:2组患者基线TAOC、MDA及TAOC/MDA差异无统计学意义。观察组用药≥12个月后同基线比较,TAOC水平明显升高,MDA下降(P<0.05);TAOC/MDA升高,但差异无统计学意义(P>0.05);与对照组比较,观察组TAOC升高,MDA减低(P<0.05)。结论:>60岁老年冠心病患者行参松养心胶囊治疗,可明显增加机体TAOC,降低MDA水平,可降低氧化应激所致冠状动脉粥样硬化风险。Objective： To explore the effect of Shensong Yangxin Capsules on total antioxidative capability （TAOC） in elderly patients with coronary heart disease （CHD）. Methods： A total of 82 consecutive elderly patients with CHD （survey group） were involved, Shensong Yangxin Capsules were taken orally t〉 12 months. A total of 80 consecutive patients with CHD but not taken that drugs were to be the controls. TAOC and MDA were measured before intake of drugs and 12 months later in all patients. Results： There was no significant difference in the levels of TAOC and MDA in base line between 2 groups. The levels of TAOC after intake of drugs 12 months in survey group were significantly higher than that in base line, but the levels of MDA were lower （P 〈0. 05）, and TAOC/MDA was higher, but there was no significant difference （ P 〉 0. 05 ）. The levels of TAOC were higher and the levels of MDA were lower in survey group than those in control group （ P 〈 0. 05 ）. Conclusion： The data suggests that the levels of TAOC can be promoted and the levels of MDA can be decreased when elderly patients with CHD taken orally Shensong Yangxin Capsules, and also can decrease the risk of atherosclerosis caused by oxidative stress.

关 键 词：参松养心胶囊 老年 氧化应激 冠心病 

分 类 号：R540.4[医药卫生—心血管疾病]