心率影响梗死后心绞痛发生率的国内Meta分析  

A Meta analysis for the relation of heart rate and postinfarction angina pectoris in Chinese population

作　　者：李婧[1] 陈汉想[2] 李伟[3] 

机构地区：[1]武汉科技大学附属天佑医院,湖北武汉430064 [2]武汉轻工大学医学技术与护理学院,湖北武汉430023 [3]华中科技大学同济医学院附属协和医院,湖北武汉430000

出　　处：《武汉轻工大学学报》2014年第3期116-120,共5页Journal of Wuhan Polytechnic University

摘　　要：采用Meta分析(Meta analysis)的方法确定我国人群心率对急性心肌梗死(Acute myocardia infarction,AMI)患者梗死后心绞痛发生的影响。全面收集国内发表的有关AMI患者静息心率与梗死后心绞痛关系的文献,对符合条件的所有研究结果利用RevMan软件进行固定效应模型的Meta分析。计算AMI患者心率慢组相对心率快组发生梗死后心绞痛的危险(relative risk,RR),评价心率快慢对AMI患者梗死后心绞痛发生的影响,并用漏斗图分析发表性偏倚。符合纳入标准的共7篇文献,总样本量1 888例。其中心率慢组1 030例,发生梗死后心绞痛128例;心率快组858例,发生梗死后心绞痛247例;合并RR=0.46,95%可信区间是0.38—0.55。漏斗图分析提示不存在发表性偏倚。AMI后心率增快者发生梗死后心绞痛危险增加,减慢心率可预防梗死后心绞痛的发生。By Meta analysis,we determined the influence of heart rate on postinfarction angina pectoris incidence in Chinese population with acute myocardial infarction. A comprehensive collection of an epidemiological study published domestically on the relationship between resting heart rate and postinfarction angina pectoris in AMI patients,was carried out,for making the Meta analysis by using RevMan software with fixed effects model and random effects model. We calculated the relative risk（ RR） of postinfarction angina pectoris risk of AMI patients in slow heart rate group relative to quick heart rate group,and evaluated the influence of heart rate level with AMI on occurrence of postinfarction angina pectoris,and analyzed the publication bias by funnel plot. The 7 articles were included. The total sample size was 1888 cases. There were 1030 cases in the heart rate slow group,and postinfarction angina pectoris appeared in 128 cases. The heart rate quick group was 858 cases,247 cases combined with postinfarction angina pectoris; RR = 0. 46,95% confidence interval was（ 0. 38-0. 55）. Funnel plot analysis showed no presence of publication bias. There is a correlation between heart rate level and postinfarction angina pectoris occurrence in AMI patients. Postinfarction angina pectoris is increased in heart rate quick patients. Slowing down the heart rate may reduce the risk of postinfarction angina pectoris.

关 键 词：心率 急性心肌梗死 梗死后心绞痛 综合分析 

分 类 号：R541.4[医药卫生—心血管疾病]