不同剂量阿托伐他汀治疗老年人高脂血症的疗效和安全性观察  

Efficacy and safety in different doses of atorvastatin for elderly hyperlipidemia

作　　者：程天一 王俊 施争艳 

机构地区：[1]上海市打浦桥街道社区卫生服务中心,上海200023 [2]上海市龙华街道社区卫生服务中心,上海200232

出　　处：《上海预防医学》2014年第9期484-486,共3页Shanghai Journal of Preventive Medicine

摘　　要：[目的]观察不同剂量的阿托伐他汀对老年人高脂血症的疗效和安全性。[方法]收集符合要求的高脂血症老年人153例,随机分为阿托伐他汀低剂量组(10 mg/d,A组)79例和常规剂量(20 mg/d,B组)74例。分别在治疗前及治疗后第2、8周采集空腹静脉血,比较两组间治疗前后血脂的差异、疗效,并观察肝、肾、肌肉的不良反应。[结果]治疗8周后,A、B组总胆固醇分别下降19.6%、20.0%,低密度脂蛋白胆固醇分别下降17.4%、20.1%,治疗前后差异均有统计学意义(P均<0.01);两组间血脂水平差异无统计学意义(P>0.05)。A、B组治疗后均未发现肝、肾、肌肉的不良反应,差异无统计学意义(P>0.05)。A组治疗后尿酸水平较治疗前下降,差异有统计学意义(P<0.01);两组间治疗后不良反应总体差异无统计学意义(P>0.05)。[结论]口服阿托伐他汀10 mg/d与20 mg/d同样可使老年人血总胆固醇及低密度脂蛋白胆固醇下降。与20 mg/d阿托伐他汀相比,10 mg/d口服无明显肝、肾、肌肉不良反应。10 mg/d组在降脂同时还能降低血尿酸水平,对老年人的降脂治疗是安全、有效的。[Objective] To investigate the efficacy and safety in different doses of atorvastatin for elderly hyperlipidemia. [Methods] A total of 153 elderly patients with hyperlipidemia were included,who were randomly divided into two groups. Group A（ n = 79） received 10 mg /d atorvastatin,and group B（ n =74） 20 mg/d. Before and after treatment of 2 weeks,8 weeks,were checked the level of blood lipid,functions of liver and kidney,creatine kinase,creatine kinase isoenzymes. [Results] After treatment,the level of TC（ cholesterol） was reduced by 19. 6%（ A） and 20. 0%（ B） respectively in the two groups.LDL-C（ low density lipoprotein cholesterol） decreased by 17. 4%（ A） and 20. 1%（ B） respectively in the two groups. The level of TC,LDL-C in the two groups showed no difference after treatment（ P〈0. 01）. The medicine was not found to cause adverse effect in liver and kidney function and myolysis in the two groups（ P〉0.05）. After taking medicine,The level of uric acid（ UA） was decreased in group A（ P〈 0.01）.There was no difference in the two groups（ P〉 0. 05）. [Conclusion] Oral administration of lower doses of atorvastatin not only lowers the lipid in elderly patients,but also lowers the blood uric acid. And administration of lower and higher doses of atorvastatin are both effective and safe for elderly hyperlipidemia.

关 键 词：阿托伐他汀 剂量 高脂血症 老年 

分 类 号：R589.2[医药卫生—内分泌]