维生素D受体基因多态性与2型糖尿病易患性的Meta分析  

Polymorphisms of Vitamin D Receptor Genes and Susceptibility of Type 2 Diabetes Mellitus:A Meta- analysis

作　　者：侯清涛[1,2] 李舍予[1] 吕霞飞[1,2] 马骁潇 庞才双 蔡惠民 严芳芳[1,2] 李芸[1,2] 田浩明[1] 

机构地区：[1]四川大学华西医院内分泌代谢科,四川省成都市610041 [2]四川大学华西临床医学院

出　　处：《中国全科医学》2014年第27期3225-3231,共7页Chinese General Practice

基　　金：四川省卫生厅科研课题(130029)

摘　　要：目的定量分析维生素D受体(VDR)基因(ApaI、BsmI、FokI、TaqI)多态性与2型糖尿病(T2DM)易患性的关系。方法检索PubMed、EMBase、中国期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、维普网、万方数据库从建库到2013年4月发表的文献,对符合纳入和排除标准的病例对照研究按照Cochrane系统评价员手册4.2.2进行系统评价,运用Stata 12.0进行Meta分析。结果纳入33篇文献共59个研究(ApaI:14;BsmI:18;FokI:13;TaqI:14),Meta分析结果显示FokI位点单核苷酸多态性与T2DM易患性存在相关性〔等位基因f与F:OR=1.31,95%CI(1.09,1.57),P=0.004〕,其中亚洲人关联更为明显〔等位基因f与F:OR=1.34,95%CI(1.09,1.65),P=0.005〕,而ApaI、BsmI、TaqI位点单核苷酸多态性与T2DM易患性不存在相关性。结论VDR基因FokI位点单核苷酸多态性与T2DM发病风险相关,其中f可能为T2DM的易患基因。Objective To quantitatively investigate the association between the polymorphisms of the vitamin D receptor（ VDR） genes（ ApaI,BsmI,FokI,TaqI） and the susceptibility of type 2 diabetes mellitus（ T2DM）.Methods Databases of PubMed,EMBase,CNKI,CBM,VIP,and Wanfang Data were searched from the date of their establishment till April2013.All case control studies which matched both the inclusive criteria and exclusive criteria were subjected to systematic review based on Cochrane Reviewers＇ handbook 4.2.2 and Meta- analysis conducted on Stata 12.0 software.Results Thirty- three articles and fifty- nine studies were included（ ApaI： 14; BsmI： 18; FokI： 13; TaqI： 14）.The results of Meta- analysis indicated that the polymorphism of VDR FokI alleles was significantly associated with the susceptibility of T2 DM 〔allele f vs.F：OR = 1.31,95% CI（ 1.09,1.57）,P = 0.004 〕,especially in Asians 〔alleles f vs.F： OR = 1.34,95% CI（ 1.09,1.65）,P = 0.005 〕.However,no significant association was observed between ApaI,BsmI or TaqI polymorphisms and T2 DM.Conclusion VDR gene FokI polymorphism may increase the risk of T2 DM,and allele f may be the predisposing gene.

关 键 词：糖尿病 2型 受体 骨化三醇 多态性 单核苷酸 META分析 

分 类 号：R587.1[医药卫生—内分泌]