血清25羟维生素D_3与2型糖尿病周围神经病变的相关性  

Correlation between serum level of 25-hydroxy vitamin D_3 and peripheral neuropathy in patients with type 2 diabetes

作　　者：佘敦敏 朱妍 冯尚勇 罗娜 王艳 张真稳 

机构地区：[1]扬州大学临床医学院内分泌科,扬州225001

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2014年第3期240-243,共4页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：目的探讨血清25OH维生素D3(25OHD3)水平与2型糖尿病周围神经病变的关系。方法收集114例2型糖尿病患者,根据临床症状、体征和电生理检查,将患者分为糖尿病合并周围神经病变组(63例)和非糖尿病周围神经病变组(51例),抽取所有受试者空腹静脉血检测血清25OHD3水平,比较2组患者血清25OHD3水平,分析25OHD3与2型糖尿病临床指标间的相关性。结果糖尿病周围神经病变组较非糖尿病周围神经病变组患者维生素D3缺乏发生率分别是79.4%和41.2%,差异有统计学意义(P<0.01);糖尿病周围神经病变组患者25OHD3水平低于非糖尿病周围神经病变组,分别为(40.1±12.7)nmol/L与(54.4±18.4)nmol/L,差异有统计学意义(P<0.01);25OHD3水平与2型糖尿病患者糖化血红蛋白(HbA1c)及糖尿病病程负相关(P值分别为0.01和0.044)。结论低25OHD3水平是2型糖尿病周围神经病变的危险因素,25OHD3水平与2型糖尿病患者病程和HbA1c相关。Objective To investigate the correlation between serum level of 25-hydroxy vitamin D3 （25OHD3） and peripheral neuropathy in patients with type 2 diabetes .Methods A total of 114 type 2 diabetic patients were enrolled into the study.Among them, 63 patients were diagnosed as diabetic peripheral neuropathy according to clinical symp -toms, signs and electrophysiological sensory testing .The serum levels of 25OHD3 were determined and analysed . Results The frequency of vitamin D deficiency was significantly higher in neuropathic patients than in non -neuropathic patients, the frequencies were 79.4%and 41.2% （P〈0.01）.25OHD3 levels of neuropathic patients were significantly lower than non-neuropathic patients, the values were （40.1 ±12.7 nmol/L vs 54.4 ±18.4 nmol/L） （P〈0.001）.The level of 25OHD3 was associated with HbA1c and the duration of type 2 diabetes （P=0.01 and P=0.044）.Conclusion Low level of 25OHD3 is a risk factor for diabetic neuropathy in type 2 diabetic patients.The level of 25OHD3 is associated with the duration of type 2 diabetes and HbA1c.

关 键 词：维生素D 糖尿病神经病变 2型糖尿病 

分 类 号：R681[医药卫生—骨科学]