芪药消渴胶囊逆转2型糖尿病慢性肾脏疾病白蛋白尿的临床观察  

Study on QiyaoXiaoke capsule reversing microalbminurina in chronic kidney disease of type 2 diabetes mellitus

作　　者：倪青[1] 姜山[1] 肖月星[1] 冯兴中[2] 李建民 朱章志[4] 刘敏[4] 魏爱生[5] 苏秀海[6] 高天舒[7] 胡筱娟 袁志敏[9] 张效科[9] 

机构地区：[1]中国中医科学院广安门医院内分泌科,北京100053 [2]北京世纪坛医院内分泌科 [3]北京中西医结合医院内分泌科 [4]广州中医药大学第一附属医院内分泌科 [5]广东佛山市中医院内分泌科 [6]河北省沧州中西医结合医院内分泌科 [7]辽宁中医药大学附属医院内分泌科 [8]陕西省中医医院内分泌科 [9]陕西中医学院附院内分泌科

出　　处：《中国糖尿病杂志》2014年第9期808-810,共3页Chinese Journal of Diabetes

基　　金：陕西省"13115"科技创新工程重大科技产业化计划项目(2008ZDCY-25);咸阳市科技计划项目[XK0914-2(3);2011K13-05(2)]

摘　　要：目的 观察芪药消渴胶囊对糖尿病慢性肾脏疾病（CKD）白蛋白尿的影响. 方法 采用多中心、随机、双盲、安慰剂对照试验,共224例UAlb/Cr 30～299 mg/24 h患者纳入研究,其中试验（Tre）组116例,对照（PC）组108例,两组在接受常规治疗的基础上,Tre组加用芪药消渴胶囊,PC组加用安慰剂,治疗16周.比较两组治疗前后UAlb/Cr、肾功能、血糖、血脂等指标的变化. 结果 与治疗前相比,治疗后两组UAlb/Cr、肾功能、血糖、血脂等指标均有所改善（P＜0.05）,Tre组与PC组相比差异有统计学意义（P＜0.05）. 结论 芪药消渴胶囊能够逆转患者UAlb/Cr 30～299 mg/24 h水平,保护肾功能,延缓CKD的进展.Objective To observe the influence of QiyaoXiaoke capsule on rnicroalbminurina in T2DM with chronic kidney disease （CKD）. Methods The multicenter, randomized, double-blind and placebo control experiments were performed in this study. 224 eases of patients with CKD were observed, which was divided into trial （Tre） group with 116 patients and placebo control （PC） group with 108 patients. Two groups were treated with routine treatment for 16 weeks, Tre group was given QiyaoXiaoke capsule as add-on therapy to the routine treatment, PC group was given placebo capsule. The aim was to compare blood glucose, blood lipid, renal function, UAlb/Cr. Results After treatment, UAlb/Cr, renal function, blood glucose and blood lipid are improved （P〈0.05）. In addition, the improvement in Tre group was superior to that in PC group （P〈0.05）. Conclusion QiyaoXiaoke capsule can reverse microalbuminuria in CKD, protect renal function, and delay the progression of CKD.

关 键 词：芪药消渴胶囊 糖尿病慢性肾脏疾病 白蛋白尿 中药 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]