血栓前体蛋白和抗凝血酶Ⅲ在糖尿病微血管病变患者中的变化及与脑梗死的相关性研究  

The changes of thrombus premise protein and antithrombin Ⅲ activity in patients with diabetic microangiopathy and its correlation with cerebral infarction

作　　者：何艳[1] 唐义平[2] 

机构地区：[1]宜宾市第二人民医院老年医学科,644000 [2]四川省人民医院老年内分泌科

出　　处：《中国糖尿病杂志》2014年第9期830-832,共3页Chinese Journal of Diabetes

摘　　要：目的探讨糖尿病微血管病变患者体内血栓前体蛋白(TpP)浓度和抗凝血酶Ⅲ(AT-Ⅲ)活性改变及其与糖尿病合并脑梗死的关系。方法选取糖尿病微血管病变患者101例和正常对照(NC)者31名,观察各组TpP浓度、AT-Ⅲ活性变化及脑梗死发生的风险指标。结果与NC组相比,糖尿病微血管病变组TpP浓度高[(5.53±3.16)vs(3.86±1.37)μg/ml,P<0.05]、AT-Ⅲ活性低[(92.26±13.97)%vs(102.24±10.45)%,P<0.05]。糖尿病微血管病变合并脑梗死亚组、糖尿病微血管病变未合并脑梗死亚组和NC组TpP浓度、AT-Ⅲ活性比较差异有统计学意义[(6.82±4.12)vs(4.88±2.32)vs(3.86±1.37)μg/ml,P<0.05;(86.21±13.47)%vs(95.33±13.30)%vs(102.24±10.45)%,P<0.05]。Logistic多元回归分析显示,年龄、SBP、TpP、AT-Ⅲ与脑梗死发生独立相关。结论糖尿病微血管病变组TpP浓度升高,AT-Ⅲ活性降低,糖尿病患者机体处于血栓前状态,存在血栓形成风险。糖尿病患者联合检测血浆TpP浓度和AT-Ⅲ活性,有助于血栓性疾病的早期发现及治疗。Objective To investigate the relationship between the changes of thrombus precursor protein(TpP)concentrations and antithrombin Ⅲ(AT-Ⅲ)activity and the diabetic thrombotic complications in patients with diabetic microangiopathy. Methods 101 hosaipitalized patients with diabetic microangiopathy and 31 normal control(NC)people were selected.The differences of TpP concentrations and AT-Ⅲactivity were compared between two groups.The relationship between the risk indexes of cerebral infarction was also statistically analyzed. Results Compared with NC group,serum TpP concentrations were significantly higher in diabetic microangiopathy group[(5.53±3.16)vs(3.86±1.37)μg/ml,P<0.05],and AT-Ⅲ activity were lower[(92.26±13.97)%vs(102.24±10.45)%,P<0.05].There was statistical difference in serum TpP concentrations and AT-Ⅲ activity among diabetic cerebral infarction subgroup,diabetic cerebral infarction subgroup and NC group[(6.82±4.12)vs(4.88±2.32)vs(3.86±1.37)μg/ml,P<0.05;(86.21±13.47)%vs(95.33±13.30)%vs(102.24±10.45)%,P<0.05].Multiple logistic regression analysis showed that cerebral infarction was significantly associated with age,SBP,TpP and AT-Ⅲ(P<0.05). Conclusion The serum TpP levels are increased while AT-Ⅲactivity is declined.It means that there might be a pre-thrombotic status in patients with diabetic microangiopathy,which is risk for thrombosis.Combined detections of TpP and AT-Ⅲ may contribute to early diagnosis and treatment of thrombotic diseases for these patients.

关 键 词：血栓前体蛋白 抗凝血酶Ⅲ 血栓前状态 糖尿病 糖尿病微血管病变 

分 类 号：R587.2[医药卫生—内分泌]