地特胰岛素在特殊类型糖尿病患者中的应用  

The application of insulin detemir in specific diabetic population

作　　者：周岩[1] 姬秋和[2] 

机构地区：[1]解放军451医院内分泌科,西安710032 [2]第四军医大学西京医院内分泌科

出　　处：《中国糖尿病杂志》2014年第9期862-864,共3页Chinese Journal of Diabetes

摘　　要：基础胰岛素类似物(地特胰岛素,Det)对于T1DM患儿和青少年,使用灵活、夜间低血糖风险小,餐后低血糖风险小,提高了患者及家庭的生活质量。妊娠期糖尿病(GDM)优化血糖管理有助于改善孕妇和新生儿的预后,Det能提供良好的血糖控制,且在孕妇中耐受良好。对于老年糖尿病患者,低血糖与心肌梗死、死亡风险、痴呆及骨折等不良事件相关,其可提供有效的血糖控制且对老年患者低血糖风险小。Det由于其作用特点,满足了特殊糖尿病患者的治疗需求。This review aimed to assess the application of basal insulin analogs（insulin detemir,Det） in the diabetic specific populations. All children with type 1 diabetes mellitus require insulin therapy. Det can offer flexibility：, reduction of nocturnal hypoglycemic episodes and decrease in postprandial hyperglycemic events,resulting in improved quality of life for diabetic children and their families. Excellent glycemic control is essential in pregnancy to optimize maternal and fetal outcomes. Det can provide good glycemic control and be well tolerated in gestational diabetes. In elderly patient a history of hypoglycemia is correlated with myocardial infarction,mortality, dementia and fracture. Treatment with Det can provide effective glycemic control without serious hypoglycemia in elderly patients. Basal insulin detemir has characteristics that may meet the treatment needs of diabetic specific populations.

关 键 词：特殊人群 糖尿病 长效胰岛素 地特胰岛素 

分 类 号：R587.1[医药卫生—内分泌]