基于真实世界的病毒性肝炎患者临床特征与用药分析  

Study of clinical character and medicinal therapy of viral hepatitis in hospital based on real world

作　　者：李蕴铷[1,2] 王连心[1] 谢雁鸣[1] 杨薇[1] 王卓月 易丹辉[3] 王永炎[1] 

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]首都医科大学附属北京地坛医院,北京100015 [3]中国人民大学,北京100872

出　　处：《中国中药杂志》2014年第18期3448-3453,共6页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502030);中国中医科学院基本科研业务费自主选题项目(ZZ0808016)

摘　　要：病毒性肝炎是我国传染病住院患者中最常见的一类疾病,但由于其收治医院包括传染病专科医院、综合医院和中医院等不同类型的医院,对其分型、诊断标准及治疗方案的尚存在较大的差别,因此有必要对多家不同医院住院的病毒性肝炎患者的信息进行综合分析。该文以17家三级甲等医院HIS数据库中41 180例病毒性肝炎住院患者为研究对象,分析其一般信息、亚型分布、病情预后、合并疾病、发病和节气的关系及治疗药物。研究发现患者中以18-59岁的中青年男性多见;入院方式以普通门诊为多;医保为最常见医疗支付方式;从预后角度看,急性肝炎好于慢性者,年轻患者好于年老者,女性好于男性;合并疾病中以肝硬化和肝脏恶性肿瘤为多见;发病高峰为夏至、小暑和大暑3个节气;关于治疗药物,化学药以还原型谷胱甘肽为最常见,中药以甘草酸二胺最常见,中西药联合治疗是最多见的治疗模式,联合用药模式中以甘草酸二胺联合还原型谷胱甘肽、胸腺肽和多烯磷脂酰胆碱为主。由于该文为回顾性描述分析,疗效和治疗方案的之间的相关性未做分析,因此仅供临床医生在治疗选择中作参考。Viral hepatitis was the most common infectious disease in china.But the diagnosis and treatment were varied because the viral hepatitis patients were hospitalized in different kinds of hospital such as infectious disease hospital,general hospital and Chinese medical hospital.It was necessary to know clinical characters and information of viral hepatitis patients in different hospitals.The general information,subtype distribution,prognosis,complication,medication and relations of onset with solar term from 41 180 viral hepatitis patients based on HIS data were analyzed.It was found that the age of patients between 18 to 59 years old was most;most patients were males.The national basic medical insurance was the most type of payment.The outcome of viral hepatitis in the youth and female were better than that in the old and male.Acute hepatitis was easer to restore than chronic hepatitis.Liver cirrhosis and hepatocellular carcinoma were the two most complications.The peak of onset was during summer solstice,slight heat and great heat.The most common Chinese medicine was Diammxmium glycyrrhizinate and the most common western medicine was reduced glutathione.The combination of D.glycyrrhizinate with reduced glutathione,polyene phosphatidylcholine and thymosin was the main pattern.But It was not knew if the combination of western and Chinese medicine was the most effective therapy to protect liver function.It was necessary to take deeply research of the relationship between the combination therapy and their effectiveness.

关 键 词：病毒性肝炎 真实世界 医院信息系统 联合用药方案 

分 类 号：R512.6[医药卫生—内科学]