人纤溶酶原K5联合化疗和放疗对小鼠S180实体瘤的抑制作用  

Inhibitory effects of plasminogen K5 combined chemotherapy and radiotherapy on S180 solid tumor in mice

作　　者：张迪[1] 边六交[2] 张李婷[1] 封卫毅[1] 

机构地区：[1]西安交通大学医学院第一附属医院药学部,西安710061 [2]西北大学,西安710061

出　　处：《西北药学杂志》2014年第5期477-480,共4页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:81372379);十一五国家科技重大专项重大新药创制项目(编号:2009ZX09103-696)

摘　　要：目的观察人纤溶酶原K5联合化学及放射治疗对小鼠S180实体瘤的抑制作用。方法将小鼠随机分为7组,阴性对照组、化疗组/放疗组、艾迪组+化疗组/甘氨双唑钠+放疗组、化疗/放疗+K5大剂量组、化疗/放疗+K5中剂量组、化疗/放疗+K5小剂量组及K5中剂量组,连续给药10d,观测肿瘤的大小,计算抑瘤率。结果 K5联合化学治疗可以明显增强其抑制肿瘤生长的效果,并有一定的剂量依赖性,而K5联合放射治疗可以增强其抑制肿瘤生长的效果。结论 K5可能为一种新型的治疗肿瘤的药物,但是K5与化学及放射联合治疗的具体机制尚待进一步研究。Objective To investigate the inhibitory effects of human plasminogen kringle 5（K5） combined chemotherapy and radio-therapy on S180 solid tumor in mice .Methods The mice with S180 solid tumor were randomly divided into seven groups ,control group ,chemotherapy group/radiotherapy group , Aidi injection ＋ chemotherapy group/ glycididazole sodium ＋ radiotherapy group ,chemotherapy /radiotherapy ＋ K5 high-dose group ,chemotherapy /radiotherapy ＋ K5 medium-dose group ,chemothera-py /radiotherapy ＋ K5 small-dose group and K5 medium-dose group .The size of tumor and the rate of tumor-inhibition after in-jecting 10 days ,were used to evaluate the inhibitory effects .Results K5 combined chemotherapy could significantly increase the inhibition of tumor grow th in a dose-dependent manner ,and K5 combined radiotherapy also could moderately increase the inhibi-tion of tumor growth .Conclusion These results suggest that K5 may be a new drug of tumor therapy ,but inhibitory mechanism of K5 combined chemotherapy and radiotherapy needs to be studied further .

关 键 词：纤溶酶原K5 S180实体瘤 血管生成 

分 类 号：R965[医药卫生—药理学]