461株儿童感染肺炎链球菌的临床分布及耐药性分析  

Analysis on the separation and drug-resistance of 461 strains of Streptococcus pneumoniae from children

作　　者：李玲萍[1] 江咏梅[1] 周伟[1] 旷凌寒[1] 

机构地区：[1]四川大学华西第二医院检验科,四川成都610041

出　　处：《现代预防医学》2014年第18期3331-3333,3339,共4页Modern Preventive Medicine

摘　　要：目的对儿童肺炎链球菌的临床分离情况和耐药性进行分析,了解近年来肺炎链球菌对儿童所致的主要感染,同时了解耐药性的变迁情况,为临床合理用药提供依据。方法对某院2008年1月至2013年5月间儿科送检培养标本进行细菌培养及药物敏感性分析。结果近6年时间共分离出肺炎链球菌461株,标本种类近10种,主要标本为痰,占92.0%,其他标本种类主要为血液、脑脊液等。在分离出的肺炎链球菌中,有9.76%对青霉素耐药,99.57%对红霉素耐药,大部分菌株表现为对头孢噻肟(73.10%)和左旋氧氟沙星(99.57%)敏感,未发现对万古霉素耐药菌株。结论应加强对儿童肺炎链球菌耐药性的研究,降低肺炎链球菌所致儿童感染的几率,减少抗生素的不合理使用,为临床诊疗提供依据。Objective This study was conducted to understand the separation of clinical bacterial and drug-resistance of Streptococcus pneumoniae infection for children in Sichuan, in order to investigate the changes of Streptococcus pneumoniae in recent years, and improve the rational use of drug in clinical practice, Methods The study was conducted by a retrospective analysis in the west China second university hospital from January 2008 to May 2013. Results Four hundred and sixty-one strains of Streptococcus pneumoniae were separated during the six years. There were ten varieties of sample types including sputum, blood, cerebrospinal fluid, and so on. The separation was mainly from the sputum （92.0%）. The drug-resistance rate towards penicillin and erythromycin was 9.76% and 99.57%, respectively. Most of the Streptococcus pneumoniae were more sensitive to cefotaxime （73.10%）, and ofloxacin （99.57%）. Vancomycin resistant strain was not identified. Conclusion It was of great importance to reinforce the study of drug-resistance of Streptococcus pneumoniae, reduce the incidence of infection caused by Streptococcus pneumoniae in children, and decrease the irrational use of antibiotics.

关 键 词：儿童 肺炎链球菌 抗生素 耐药性 

分 类 号：R725.6[医药卫生—儿科]