高血压患者颈动脉斑块与血浆同型半胱氨酸的相关性研究  

Correlation Study for Plasma Homocysteine Level and Carotid Plaque in Patients With Essential Hypertension

作　　者：曾双龙[1] 徐俊波[1] 胡咏梅[1] 

机构地区：[1]成都市第二人民医院心内科,四川省610017

出　　处：《中国循环杂志》2014年第9期690-693,共4页Chinese Circulation Journal

基　　金：2011年四川省医学会施慧达药业集团(吉林)有限公司科研研究基金(SHD11-04)

摘　　要：目的:探讨高血压患者颈动脉斑块与血浆同型半胱氨酸(HCY)的相关性。方法:选择高血压患者410例,根据颈动脉血管彩超将其分为两组:颈动脉斑块阴性者为对照组(n=138),颈动脉斑块阳性者为试验组(n=272)。比较两组患者基线情况,使用Spearman相关及Logistic回归分析颈动脉斑块与心血管影响因素的相关性。结果:试验组患者与对照组比较,男性比例高、年龄大、血肌酐、脉压及血浆HCY水平较高,差异均有统计学意义(P<0.05)。逐步Logistic回归分析显示仅年龄与颈动脉斑块呈独立相关(比数比为1.059,P=0.001)。结论:高血压患者血浆HCY与颈动脉斑块非独立正相关。Objective： To explore the relationship between plasma homocysteine level and carotid plaque in patients with essential hypertension （EH）. Methods： A total of 410 EH patients were divided into 2 groups according to carotid color ultrasound screening. Control group, n=138 patients without carotid plaque and Carotid plaque group, n=272. The baseline condition was compared between 2 groups, the correlation between carotid plaque and homocysteine level with other cardiovascular risk factors were studied by Spearman correlation and logistic regression analysis. Results： Compared with Control group, the patients in Carotid plaque group had more male gender, elder age, higher levels of creatinine, pulse pressure and homocysteine, all P〈0.05. Logistic regression analysis indicated that only the age was independently related to carotid plaque （OR 1.059, P=0.001） in EH patients. Conclusion： Homocysteine level was positively but not independently related to carotid plaque formation in EH patients.

关 键 词：高血压 颈动脉斑块 同型半胱氨酸 相关性 

分 类 号：R541[医药卫生—心血管疾病]