青蒿素固体脂质纳米粒的制备  

Study on the preparation of artemisinin-loaded solid lipid nanoparticle formulation

作　　者：傅川[1] 朱九群[2] 曾明辉[3] 何林[2] 

机构地区：[1]重庆医科大学附属永川医院药学部,重庆402160 [2]四川省医学科学院四川省人民医院药学部,四川成都610072 [3]邛崃市医疗中心医院药学部,四川邛崃611350

出　　处：《中国医院药学杂志》2014年第18期1546-1550,共5页Chinese Journal of Hospital Pharmacy

基　　金：四川省卫生厅课题(编号:130547)

摘　　要：目的:优化青蒿素固体脂质纳米粒(ART-SLN)的制备工艺。方法:采用溶剂乳化蒸发法制备ART-SLN。以投药量、大豆磷脂用量和表面活性剂浓度为考察因素,粒径和载药量为评价指标,根据球面设计原理安排实验,并用二项式拟合建立各指标与因素间的关系,经效应面法预测最佳工艺条件。结果:经拟合后的ART-SLN的制备处方为1.4 mg青蒿素、0.75%表面活性剂、22.5 mg的大豆磷脂,制得的ART-SLN其粒径为233.4 nm,载药量为2.32%。结论:ART-SLN的处方优化成功,达到了预期目的。OBJECTIVE To optimize the artemisinin（ART）-loaded solid lipid nanoparticle （ART-SLN） preparation. METH- ODS Solvent emulsification evaporation was chosen as the preparation method of ART-SLN. Central composite design-re- sponse surface methodology was used to optimize the formulation by investigating the factors of the dosage of ART, the surfac- rant amount of soybean phosphilipids and the concentration of F68. The size of SLN and the drug loading were selected as eval- uation index. RESULTS The optimal formulation was composed of 1.4 mg ART, 0. 75% F68 and 22. 5 mg soybean lecithin respectively. The size and drug loading of the prepared ART-SLN were 233.4 nm and 2. 32%, respectively. CONCLUSION The preparation process and formulation of the ART-SLN were successfully screened and optimized.

关 键 词：青蒿素 固体脂质纳米粒 球面设计法 

分 类 号：R284.1[医药卫生—中药学] R917.101[医药卫生—中医学]