2009-2012年山东省流感样病例流行病学及病原学特征分析  

Analysis on the epidemiology and etiology data of influenza like illness cases in Shandong Province from 2009 to 2012

作　　者：宋绍霞[1] 王宇路[1] 张圣洋[1] 刘倜[1] 林艺[1] 孙林[1] 李忠[1] 王显军[1] 徐爱强[1] 毕振强[1] 

机构地区：[1]山东省疾病预防控制中心,山东济南250014

出　　处：《现代预防医学》2014年第19期3466-3469,共4页Modern Preventive Medicine

基　　金：山东省科技厅计划项目(2009GG10002054)

摘　　要：目的掌握2009-2012年山东省流行性感冒流行规律,病毒型别及其活动水平,为流感的监测预警提供信息。方法收集2009-2012年山东省流感监测系统流感样病例(ILI)监测资料和ILI鼻咽拭子标本的流感病毒检测结果资料进行分析。结果 2009-2012年4个年度,哨点医院内科(儿内科)门诊患者合计19 877 694例,其中ILI 446 406例,占2.25%。4个年度ILI%分别为3.16%、1.98%、2.11%和2.01%,4个年度ILI%差异有统计学意义(P<0.05);74.0%的ILI集中在5岁以下年龄组。合计检测ILI标本40 257份,检出流感阳性标本8 960份,阳性率为22.39%。4个年度流感病毒检测阳性率分别为48.67%、17.28%、8.90%和14.04%。对ILI%与病毒分离率两条序列进行等级相关分析,相关系数为0.874(P<0.05),为正相关关系。结论 2009年流感病毒活动较为活跃,4个年度中流感优势病毒亚型之间呈交替变化并有一定的规律,ILI流行趋势与流感病毒活动趋势高度一致。Objective To understand the epidemic rules,viral type and activity level of influenza in Shandong Province from 2009 to2012,to provide scientific information for supervision and early warning of influenza.Methods Influenza like illness data were filled in web based forms,and throat and nasal swabs were collected in monitoring.Influenza virus was isolated in MDCK cell line.And influenza virus type was identified with hemagglutination inhibition test.Results During the past four years,influenza like illness accounted for 2.25 % of the total outpatients（446 406 out of 19 877 694）.The ILI% of each year was 3.16%,1.98%,2.11% and2.01%,respectively.Statistical analysis results showed there was a difference between ILI%（P〈0.05）.74.0% of ILI cases was children younger than 5.In total,40 257 specimen had been detected,from which 8 960 specimen（22.42%） was tested positive.From 2009 to 2012,the positive rate was 48.67%,17.28%,8.90% and 14.04%,respectively（P〈0.05）.Spearman correlation analysis,r=0.874（P〈0.05）,showed ILI% and isolating rate of virus strain were positively correlative.Conclusion Influenza virus is more active in 2009.The preceding strain changes with some uncertain rules.The epidemic character of ILI and active trend of influenza virus are highly similar.

关 键 词：流感样病例 流行病学 病原学 

分 类 号：R183[医药卫生—流行病学]