慢性特发性血小板减少性紫癜发病机制研究进展  

Advances in pathogenesis of chronic idiopathic thrombocytopenic purpura

作　　者：李珊珊[1] 蒋慧[1] 

机构地区：[1]上海交通大学附属儿童医院上海市儿童医院血液肿瘤科,200040

出　　处：《国际儿科学杂志》2014年第5期534-537,共4页International Journal of Pediatrics

基　　金：上海市科委重大课题子项目（12411952406）

摘　　要：特发性血小板减少性紫癜是一种异质性自身免疫性疾病，是儿童最常见的出血性疾病，尤其慢性患儿的健康相关生活质量受到严重影响，但其病因及发病机制目前仍不清楚。研究发现，遗传因素可能参与该病的发生及预后。该文从其危险因素、基因多态性和表达水平与其易患性及病情严重情况的关系、表观遗传的作用、慢性难治性特发性血小板减少性紫癜相关研究等方面作一综述。Idiopathic thrombocytopenic purpura （ITP）,as a heterogeneous autoimmune disease,is the most common bleeding disorder,of which etiology and pathogenesis are still unclear. Health related quality of life are severely affected,especally in chronic patients . Studys on chronic idiopathic thrombocytopenic purpura pathogenesis ,both in China and abroad,have found that genetic factors may be involved in the occurrence and prognosis of the disease. The paper gives a review from the follow aspects,such as its risk factors,relationship between genetic polymorphisms or expression levels and chronic ITP susceptibility and seriousness,the role of epigenetic,researchs about chronic and refractory ITP,et al.

关 键 词：慢性特发性血小板减少性紫癜 基因多态性 基因表达 表观遗传 

分 类 号：R554.6[医药卫生—血液循环系统疾病]