线粒体通透件转换孔在缺血/再灌注损伤中的作用  

The role of mitochondrial permeability transition pore in ischemia/reperfusion injury

作　　者：刘洁[1] 韩非[1] 

机构地区：[1]哈尔滨医科大学附属第三医院麻醉科,150081

出　　处：《国际麻醉学与复苏杂志》2014年第9期839-842,共4页International Journal of Anesthesiology and Resuscitation

基　　金：黑龙江省教育厅海外学人科研资助项目（1155h009）

摘　　要：背景 线粒体作为“能量工厂”提供细胞生长及代谢所需的三磷酸腺苷（adenosine triphosphate,ATP）,同时也是细胞存活与否的重要信号管理者.线粒体通透性转换孔（mitochondrial permeability transition pore,mPTP）是横跨线粒体内外膜之间的允许相对分子质量1.5 kD以下的分子自由通过的孔道.在脑缺血/再灌注（ischemia/reperfusion,I/R）损伤中,线粒体是研究的焦点,而mPTP作为线粒体的门户更是影响着线粒体膜电位（mitochondrial membrane potential,△ψm）、线粒体Ca2＋超载及促细胞死亡物质释放等一系列过程. 目的 对mPTP在I/R损伤中可能的作用机制及治疗方法进行综述. 内容 整理和阐述了mPTP的结构、mPTP与I/R损伤的机制和预防与治疗I/R损伤的可能方法. 趋向 随着mPTP在I/R损伤中的作用机制不断被揭示,其将成为治疗I/R损伤的重要靶点.Background Mitochondrial as a crucial organelle provides adenosine triphosphate （ATP） for cell growth and metabolism.Mitochondrial permeability transition pore （mPTP） defines as the opening pores located between the mitochondrial inner and outer membrane that allows free diffusion of all solutes 〈1.5 kD.The effect of mPTP in brain ischemia/reperfusion （I/R） injury has become a focal point.It plays a key role in mitochondrial membrane potential （Aψm）,mitochondrial Ca2＋ overload and release of triggers of cell death.Objective To review the possible mechanism and treatment methods about mPTP in I/R injury.Content This article based on series studies to explain the relationship,potential mechanism and therapy about mPTP in I/R injury.Trend mPTP will be one of key therapy targets in the I/R injury as its mechanism constantly being revealed.

关 键 词：线粒体通透性转换孔 缺血/再灌注损伤 线粒体 

分 类 号：R614[医药卫生—麻醉学]