钙黏蛋白在突触发育和突触可塑性调节中的作用  

The regulation effect of cadherin family in synaptogenesis and synaptic plasticity

作　　者：王存金[1] 庞君[1] 宋歌[1] 李莉[1] 曹俊平[1] 张励才[1] 王红军[1] 

机构地区：[1]江苏省麻醉与镇痛应用技术重点实验室,徐州医学院江苏省麻醉学重点实验室,221004

出　　处：《国际麻醉学与复苏杂志》2014年第9期860-864,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金（30901402、30900417）;江苏省高校自然科学基金（09KJD320008、08KJB180011）

摘　　要：背景 钙黏蛋白（cadherin）是一类存在于细胞表面的跨膜糖蛋白,最初被认为是一种钙离子依赖性的细胞黏附分子,主要参与调节细胞黏附、促进细胞增殖、维持细胞极性等过程.近几年对cadherin调节突触发育和突触可塑性的研究取得了较大进展. 目的 围绕cadherin在突触发育和突触可塑性过程中的作用及其相关分子机制简要作一综述,旨在为神经系统疾病的治疗提供理论依据. 内容 Cadherin的概述,cadherin在突触发育和突触可塑性调节中的作用以及相关分子机制,cadherin与神经疾病. 趋向 随着cadherin在调节突触发育和突触可塑性过程中的研究不断深入,cadherin将成为治疗神经疾病的一个新型的靶点.Background Cadherins are a group of transmembrane proteins that were originally identified as the cell-surface molecules responsible for Ca2＋ dependent cell-cell adhesion.Cadherins play important roles in the regulation of cell adhesion,cell proliferation and cell polarity.Researches have made great progress on cadherins regulating synaptogenesis and synaptic plasticity in recent years.Objective In this article we overview the roles and molecular mechanisms of cdherins in synaptogenesis and synaptic plasticity processes,aims to provide theoretical basis for the treatment of diseases of the nervous system.Content The cadherin overview,the role of cadherin in regulating synaptogenesis and synaptic plasticity and related molecular mechanisms,cadherins and nervous diseases.Trend With the development of research of cadherin in the regulation of synaptogenesis and synaptic plasticity,cadherin will become a new therapeutic target for the treatment of neurological diseases.

关 键 词：钙黏蛋白 突触发育 突触可塑性 

分 类 号：R338[医药卫生—人体生理学]