镇江市结核病耐药疫情及影响因素分析  

Analysis on epidemic situation and impact factors of drug-resistant tuberculosis in Zhenjiang city

作　　者：戴冰[1] 蒋晖[1] 夏小娟[1] 张明辉[1] 

机构地区：[1]镇江市疾病预防控制中心,江苏镇江212003

出　　处：《现代预防医学》2014年第17期3224-3226,共3页Modern Preventive Medicine

摘　　要：目的了解镇江市耐药结核病流行状况及影响因素,为我市耐药结核病的预防与控制提供依据。方法按WHO/IUATLD《结核病耐药监测指南》要求进行抽样和药物敏感性检测,抽样对象填写调查表,其监测结果运用SPSS13.0进行统计分析。结果镇江市总耐药率达41.7%,其中初始耐药率为31.1%,获得性耐药率为56.3%;单因素分析结果显示,家庭年收入〈4 200元、复治病人首次就诊机构在个体诊所、私人医院及其他、由于其他疾病应用过抗结核药物是产生耐药的危险因素,经多因素logistic分析,复治病人首次就诊机构在个体诊所、私人医院及其他是发生耐药的主要危险因素（OR=1.95,95%CI：1.139～3.336）。结论加强病人的归口管理对结核病耐药疫情的降低有重大意义。Objective To understand the epidemic situation and impact factors of drug-resistant tuberculosis in Zhenjiang City, and to provide the reference and basis for prevention and control strategy of drug-resistant tuberculosis. Methods According to WHO/IUATl D guidelines for anti-tuberculosis drug resistance surveillance, sampling and anti-tuberculosis drug resistance surveillance were conducted, questionnaires were filled up by monitored cases and the results were analyzed by SPSS13.0. Results The total drug resistance rate was 41.7%, among them initial drug resistance rate was 31.1% and acquired drug resistance rate was 56.3%.Single factor analysis showed that the family income of less than 4 200 yuan per year, retreatment cases at private clinic, private hospital or any other similar hospital, use of anti-TB drugs because of other disease before were associated with any drug resistance.The multivariate logistic regression model showed that cases retreatment at private hospital or individual clinic hospital were associated with any drug resistance（OR=1.95, 95%CI： 1.139-3.336）. Conclusion The epidemic situation of any drug resistance would be controlled with good methods of centralized manage.

关 键 词：结核病 耐药性 危险因素 

分 类 号：R117[医药卫生—公共卫生与预防医学]