抗肿瘤长循环热敏脂质体的研究进展  

Development of long-circulating thermosensitive liposomes for tumor therapy

作　　者：田伟[1] 李银贵 修宪 甄亚钦[1] 李春雷[1,2,3] 

机构地区：[1]河北医科大学药学院,石家庄050017 [2]石药集团中奇制药技术(石家庄)有限公司,石家庄050035 [3]新型药物制剂与辅料国家重点实验室,石家庄050035

出　　处：《中国新药杂志》2014年第17期2061-2065,共5页Chinese Journal of New Drugs

基　　金：国家重点基础研究发展(973)计划(2010CB735603)

摘　　要：长循环脂质体可以通过高通透性和滞留(enhanced permeability and retention,EPR)效应靶向传递药物进入肿瘤部位,但是靶向聚集的脂质体药物若不能从脂质体中释放出来则无法发挥药效。为解决此问题,长循环热敏脂质体已经成为目前的研究热点,其既保留了传统长循环脂质体的靶向作用,又能在加热条件下触发药物的局部释放,从而提高药物的治疗效果。本文综述了抗肿瘤长循环热敏脂质体的研究进展。Long-circulating liposomes encapsulated drugs could be targeted delivery to the tumor tissue based on the enhanced permeability and retention （EPR） effect. One problem of the delivery system is the low re- lease efficiency of drugs in the tumor. The long-circulating thermosensitive liposomes could not only deliver drugs to the target tissue, but also improve the release rate of the encapsulated drugs at the appropriate temperature in the tumor tissue, which can improve the therapeutic efficacy. In this article, the development of long-circulating ther- mosensitive liposomes for tumor therapy was introduced.

关 键 词：长循环 热敏脂质体 热疗 肿瘤靶向 触发释放 

分 类 号：R979.1[医药卫生—药品]