146例严重药品不良反应报告分析  

Analysis on 146 serious adverse drug reaction reports

作　　者：刘振胜[1] 杜静[1] 刘华强[1] 王红程[1] 

机构地区：[1]青岛市市立医院,山东青岛266011

出　　处：《药学研究》2014年第9期554-556,共3页Journal of Pharmaceutical Research

摘　　要：目的分析严重药品不良反应(ADR)报告表,探讨预防严重ADR发生的方法。方法对146例严重ADR报告表,分别按患者年龄、性别、报告人职业、引起ADR的药品、给药途径、临床表现等方面进行回顾性统计分析。结果 146例严重ADR中,静脉给药方式引起的严重ADR例数最多(89例,60.96%),其次为口服给药(52例,35.62%);抗菌药物引起的严重ADR最多,其次为心脑血管药物和中药制剂;ADR临床表现以过敏性休克、药物性肝炎、重症皮疹等表现为主;90例严重ADR导致住院或住院时间延长,42例危及生命。结论严重ADR的发生与多种因素有关,应增强合理用药意识,以减少和避免严重ADR的发生,保证药物治疗安全、有效。Objective Analysis of serious adverse drug reaction （ADR） report, discuss the method to prevent occur- rence of serious ADR. Methods According to patient age, gender, occupation, reported by ADR pharmaceuticals, route of administration, clinical manifestation were retrospectively analyzed. Results 146 cases of severe ADR,intravenous adminis- tration induced severe ADR cases were the most （89 cases,60.96%）, followed by oral administration （52 cases,35. 62% ） ;severe ADR antibacterial drug induced the most ,followed by cardiovascular drugs and traditional Chinese medicine; clinical manifestations of ADR in anaphylactic shock, drug - induced hepatitis, severe rash ;90 cases of severe ADR causing or prolonging hospitalization,42 cases of life - threatening. Conclusion Genesis is related to multiple factors of severe ADR,should strengthen the consciousness of rational drug use,to reduce and avoid the occurrence of serious ADR,ensure safe, effective drug treatment.

关 键 词：严重药品不良反应 静脉给药 过敏性休克 药师 

分 类 号：R969.3[医药卫生—药理学]