胎儿大脑皮层发育异常的产前超声诊断  

Study on prenatal diagnosis of fetal malformations of cortical development by ultrasonography

作　　者：马喆[1] 王音[1] 刘韶平[1] 王茜[1] 李扬 支瑞娟[1] 陶国伟[1] 

机构地区：[1]山东大学齐鲁医院超声科,济南250012

出　　处：《中华超声影像学杂志》2014年第9期804-806,共3页Chinese Journal of Ultrasonography

基　　金：教育部留学回国人员科研启动基金（20121707）;山东省自然科学基金（ZR2012HM059）;山东省卫生厅科研基金（2011HZ043）;山东省计划生育委员会科研基金

摘　　要：目的 探讨胎儿大脑皮层发育异常的产前超声表现特征.方法 回顾性分析我院2012年8月至2014年1月间同时接受超声及MRI检查的胎儿325例.结果 325例胎儿中诊断为大脑皮层发育异常14例（4％）,其中超声提示诊断10例,包括灰质异位3例,小头畸形6例,半侧巨脑症1例;超声漏诊4例,分别为脑裂畸形2例,结节性硬化1例,颞叶缺失1例.结论 大脑皮层发育异常产前影像表现具有特征性,超声联合MRI对该类疾病产前诊断具有重要作用.Objective To explore sonographic manifestation of fetal malformations of cortical development.Methods From August 2012 to January 2014 three hundred and twenty-five pregnancy women referred to our institution for fetal brain MRI,which were diagnosed or suspected of central nervous system abnormalities by prenatal ultrasound examination.Results In 325 of cases,14 cases （4%） were diagnosed of malformations of cortical development.Ten eases were indicated by prenatal ultrasound,including three cases of heterotopic gray matter,six cases of microcephaly and one case of hemimegalencephaly; four cases were missed by prenatal ultrasound,including two cases of schizencephaly,one case of tuberous sclerosis,and one case of hypoplasia.Conclusions Cortical malformations can be diagnosed by prenatal ultrasonography based on typical imaging characteristics.Prenatal ultrasound combined with MRI is a powerful tool in diagnosing fetal malformations of cortical development.

关 键 词：超声检查 产前 皮层发育异常 磁共振成像 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]