宝石CT能谱成像测定成人骨密度初步研究  

The preliminary study of bone density measurement based on CT gemstone spectral imaging

作　　者：邵伟光[1] 刘典美[1] 赵兴圣[1] 李丽新[1] 刘金刚[1] 张东雯[1] 岳奎涛[1] 

机构地区：[1]潍坊医学院附属医院影像中心,山东潍坊261031

出　　处：《实用放射学杂志》2014年第9期1524-1527,共4页Journal of Practical Radiology

摘　　要：目的 利用宝石CT能谱成像测定健康成人L3椎体骨钙含量,为能谱CT测定成人骨密度提供参考依据.方法 选取行腹部或腰椎宝石CT能谱扫描的235例患者为研究对象,其中男113例,女122例,除外有肿瘤史、外伤史、手术史及其他影响骨密度疾病的患者;年龄20～87岁,按每10岁为一年龄组,分为20～29岁、30～39岁、40～49岁、50～59岁、60～69岁、70～79岁、≥80岁组,共7个组.将扫描数据重建为层厚、间隔均为0.625 mm的Mono图像传至ADW4.4工作站,利用GSI处理器获得L3椎体水基和钙基物质图像,在椎体骨松质层面测量3个感兴趣区（ROI）,取其均值.对年龄与椎体GSI钙-水密度值、水-钙密度值行Pearson相关性分析,男女各年龄组间差异行t检验.结果 男性20～29岁组椎体GSI钙-水密度值、水-钙密度值最高,女性30～39岁组椎体GSI钙-水密度值、水-钙密度值最高,男性和女性年龄与椎体GSI钙-水密度值、水-钙密度值均呈负相关（r=-0.681 5,r=-0.887 7;r=-0,796 1,r=-0.9065;P均＜0.01）,女性≤39岁者随年龄增长椎体GSI钙水密度值、水-钙密度值呈轻度增高现象,但女性≤39岁者年龄与椎体GSI钙-水密度值、水-钙密度值间无明显相关性（r=0.190 1,P=0.373 5;r=-0.023 3,P=0.914 0）,女性≥40岁者年龄与椎体GSI钙-水密度值、水-钙密度值呈负相关（r=-0.793 9,r=-0.867 5,P均＜0.01）.男性和女性自50岁开始GSI钙-水密度值组间差异具有统计学意义（P均＜0.01）.结论 宝石CT能谱成像是测量椎体骨密度的新方法,可用来测量椎体骨密度.Objective To measure calcium concentration at 1.3 of normal aduh with CT gemstone spectral imaging （GSI） ,and to provide a reference for bone density measurement. Methods Totally,235 normal adults without tumor,trauma, surgery,and other diseases affecting bone density were included and underwent abdominal or lumbar GSI examination with spectral CT. All subjects aged 20-87 years old, 113 cases were male, 122 cases were female. The subjects were divided into seven groups according to age,i. e. 20-29,30-39,40-49,50-59,60-69,70-79,≥80 group. All the scanning data were reconstructed based on 0. 625 mm slice thickness and interval,the mono images were transmitted to ADW4.4 workstations. Calcium water and Water-calcium density values were measured with ROI at central level of 1.3 for three times,and the mean value was obtained. Age and calcium water density, wa- ter-calcium density value were underwent Pearson correlation analysis,the data between men and women in each age group was un- derwent t test. Results Males aged 20 to 29 had the highest calcium-water density and water-calcium density,females aged 30 to 39 had the highest calcium-water density and water-calcium density. Calcium-water density and water-calcium density showed negative relationship to age in both males and females （r= -0. 681 5,r=-0. 887 7; r=-0,796 1 ,r=-0. 906 5;all P〈0.01）. Calcium-wa- ter density and water-calcium density showed no correlation to age in females aged ≤39（r=0. 190 1 ,P=0. 3735;r=-0.0233,P=0. 914 0） ,there was negatively correlated in females aged ≥40 （r=-0. 793 9,r=-0. 867 5,all P〈0.01）. There was statistically significant of calcium-water density between the groups in males and females aged ≥50 （all P〈0.01 ）. Conclusion GSI is a new method in measuring bone density, it can be used to measure vertebral bone density.

关 键 词：能谱成像 计算机体层成像 骨密度 

分 类 号：R814.42[医药卫生—影像医学与核医学] R322.71[医药卫生—放射医学]